Results 41 to 50 of about 134,419 (264)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Understanding construction delay analysis and the role of pre-construction programming [PDF]
, 2013 Modern construction projects commonly suffer from delay in their completions. The resolution of time and cost claims consequently flowing from such delays continues to remain a difficult undertaking for all project parties. A common approach often relied
Braimah, N
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
AIP Advances, 2023 Here, we employ time-resolved magneto-optical Kerr system (MOKE) imaging to ascertain the origin of domain wall motion in microwires. The MOKE visualisations of the domain walls motion on the surface of the microwires prove the domain wall pinning and ...
L. Fecova, R. Varga, K. Richter
doaj +1 more source
Contralateral prophylactic mastectomy: A narrative review of the evidence and acceptability
Breast, 2021 The uptake of contralateral prophylactic mastectomy (CPM) has increased steadily over the last twenty years in women of all age groups and breast cancer stages.
Josien C.C. Scheepens +4 more
doaj +1 more source
LIPIcs, Volume 54, CPM'16, Complete Volume
, 2016 LIPIcs, Volume 54, CPM'16, Complete ...
Lewenstein, Moshe, Grossi, Roberto
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Evaluation of liver stiffness measurement–based scores in liver transplantation recipients
Liver Transplantation, EarlyView., 2022 Abstract Combining bioclinical parameters with liver stiffness measurement (LSM) has improved the diagnostic performance of vibration‐controlled transient elastography (VCTE) for detection of advanced fibrosis in patients with chronic liver disease. However, this approach has not yet been tested in liver transplantation (LT) recipients.
Tamoore Arshad +11 more
wiley +1 more source
New magic neutrino mass textures with three free parameters
Nuclear Physics B, 2023 Motivated by current experiments on searching for neutrinoless double beta decays, we study the phenomenological consequences and testability of the constraint relation “Mii= Mjj+Meμ+Meτ”, for i,j=e,μ,τ, on the magic neutrino mass matrix elements.
M.A. Ouahid +4 more
doaj +1 more source