Results 41 to 50 of about 116,381 (263)

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

open access: yesFEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen   +5 more
wiley   +1 more source

Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers

open access: yesFrontiers in Cell and Developmental Biology, 2021
BackgroundThe liver-derived plasma protein fetuin A is a systemic inhibitor of ectopic calcification. Fetuin-A stabilizes calcium phosphate mineral initially as ion clusters to form calciprotein monomers (CPM), and then as larger multimeric ...
Sina Koeppert   +8 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Gradient‐Conductivity Architecture Enables Synchronous Enhancement of Sensitivity and Detection Range in Multifunctional All‐Paper Sensors

open access: yesAdvanced Functional Materials, EarlyView.
A gradient‐engineered all‐paper sensor is fabricated by integrating MXene and in situ grown AgNPs within hierarchical cellulose networks. The device breaks the sensitivity–detection range trade‐off through cascaded conductive pathways, enabling ultrahigh pressure sensitivity, humidity–pressure decoupled dual‐mode sensing, and outstanding EMI shielding,
Ao Li   +7 more
wiley   +1 more source

Surgical repair of humerus fracture in a patient with central pontine myelinolysis

open access: yesГений oртопедии, 2020
Introduction Central pontine myelinolysis (CPM) is a rare neurologic disorder involving severe damage to the myelin sheath of nerve cells in the pons.
Andrey V. Mironov, Umar A. Ozden
doaj   +1 more source

Decay and renormalization of a longitudinal mode in a quasi-two-dimensional antiferromagnet

open access: yesNature Communications, 2021
Anisotropic spin S >1/2 quantum magnets can have multiple low energy modes. In this manuscript, the authors study the interaction of such low energy modes in the S = 1 antiferromagnet Ba2FeSi2O7 by combining neutron scattering measurements with an SU(3 ...
Seung-Hwan Do   +10 more
doaj   +1 more source

New magic neutrino mass textures with three free parameters

open access: yesNuclear Physics B, 2023
Motivated by current experiments on searching for neutrinoless double beta decays, we study the phenomenological consequences and testability of the constraint relation “Mii= Mjj+Meμ+Meτ”, for i,j=e,μ,τ, on the magic neutrino mass matrix elements.
M.A. Ouahid   +4 more
doaj   +1 more source

CPM/LOB: New Methodology to Integrate CPM and Line of Balance [PDF]

open access: yesJournal of Construction Engineering and Management, 1994
The line-of-balance technique (LOB) for planning and scheduling repetitive projects such as houses, high-rise buildings, precast concrete production, etc., has been since the 1950s and has provided unique and useful dimensions to users in perceiving when a project goes out of balance, and to its essence of capitalizing on the economy of repetition ...
Saad A. Suhail, Richard H. Neale
openaire   +1 more source

Thermal‐Driven Diode Polarity Switching From Competing Helical Superconducting States in WTe2/α‐Fe2O3 Heterostructures

open access: yesAdvanced Materials, EarlyView.
A Nb‐proximitized Josephson junction based on a WTe2/α‐Fe2O3 heterostructure exhibits a robust superconducting diode effect with programmable polarity. The diode direction can be trained by magnetic fields and switched by temperature cycling, revealing tunable finite‐momentum pairing states and competing superconducting states in symmetry‐broken ...
Enze Zhang   +9 more
wiley   +1 more source

The Potential Clinical Utility of Pressure-Based vs. Heat-Based Paradigms to Measure Conditioned Pain Modulation in Healthy Individuals and Those With Chronic Pain

open access: yesFrontiers in Pain Research, 2021
Conditioned pain modulation (CPM) is a physiological measure thought to reflect an individual's endogenous pain modulation system. CPM varies across individuals and provides insight into chronic pain pathophysiology.
Rima El-Sayed   +15 more
doaj   +1 more source

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