Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044. [PDF]
PLoS ONE, 2012 BACKGROUND: Klebsiella pneumoniae is a gram-negative, non-motile, facultative anaerobe belonging to the Enterobacteriaceae family of the γ-Proteobacteria class in the phylum Proteobacteria. Multidrug resistant K.
Vijaya Bharathi Srinivasan +3 more
doaj +4 more sources
Genomic and Functional Characterization of Multidrug-Resistant E. coli: Insights into Resistome, Virulome, and Signaling Systems [PDF]
AntibioticsIntroduction: Genetic plasticity and adaptive camouflage in critical pathogens have contributed to the global surge in multidrug-resistant (MDR) infections, posing a serious threat to public health and therapeutic efficacy.
Vijaya Bharathi Srinivasan +6 more
doaj +2 more sources
The CpxAR signaling system confers a fitness advantage for flea gut colonization by the plague bacillus. [PDF]
J BacteriolABSTRACT The adaptation of Yersinia pestis , the flea-borne plague agent, to fluctuating environmental conditions is essential for the successful colonization of the flea vector.
Robin B +7 more
europepmc +4 more sources
Regulation of drug resistance to enrofloxacin in Pasteurella multocida strains from cattle by quorum-sensing acyl-homoserine lactone signaling molecules [PDF]
Frontiers in MicrobiologyPasteurella multocida (Pm) is a significant cause of respiratory disease in beef cattle, with serious consequences for the cattle industry. The bacterial quorum-sensing (QS) system is used for communication and regulation of various processes, including ...
Miao Sun +16 more
doaj +2 more sources
Decoding the SCFA-CpxAR-OMP axis as a dietary checkpoint against antimicrobial resistance transmission across gut-environment interfaces. [PDF]
ISME JAbstract The transmission of environmental-originated antibiotic resistance genes (ARGs) into the human gut via the food chain or water has transformed the intestinal tract into a critical reservoir and dissemination hub for ARGs. Moreover, human to human oral-fecal transmission is likely to intensify this dissemination cycle.
Tan R +9 more
europepmc +2 more sources
Identificación de genes regulados por el sistema CpxAR en Serratia marcescens [PDF]
, 2023 RESUMEN Los sistemas de dos componentes (TCS, pos sus siglas en inglés) son mecanismos de señalización utilizados por las bacterias para regular la expresión diferencial de múltiples genes. El sistema CpxAR es un TCS conservado cuya función se ha relacionado principalmente con la respuesta al estrés de envoltura, sin embargo, también se ha reportado ...
Barahona, Samantha A. +3 more
openaire +3 more sources
Reducing the Periplasmic Glutathione Content Makes Escherichia coli Resistant to Trimethoprim and Other Antimicrobial Drugs [PDF]
Microbiology Spectrum, 2021 Although glutathione (GSH) has been shown to influence the antimicrobial effects of many kinds of antibiotics, little is known about its role in relation to trimethoprim (TMP), a widely used antifolate. In this study, several genes related to glutathione
Yajing Song +4 more
doaj +2 more sources
Regulation of the Pap Epigenetic Switch by CpxAR [PDF]
Molecular Cell, 2004 Pap pili gene expression is controlled by a reversible OFF/ON phase switch that is orchestrated by binding of Lrp to pap pilin promoter proximal sites 1, 2, and 3 (OFF) or pap promoter distal sites 4, 5, and 6 (ON). Movement of Lrp between proximal and distal sites controls pap pilin transcription and is modulated by PapI and DNA adenine methylase ...
Hernday, Aaron D. +4 more
openaire +3 more sources
The regulation of bacterial two‐partner secretion systems
Molecular Microbiology, Volume 120, Issue 2, Page 159-177, August 2023., 2023 Two‐partner secretion (TPS) systems play critical roles in bacterial pathogenesis by allowing the secretion of effector proteins such as cytolysins and adhesins. Here, we explore the diverse regulatory mechanisms that govern TPS system expression, including environmental stimuli, two‐component systems, quorum sensing, and global regulators, providing ...
Julian Trouillon +2 more
wiley +1 more source
Regulation of adhesin synthesis in Aggregatibacter actinomycetemcomitans
Molecular Oral Microbiology, Volume 38, Issue 3, Page 237-250, June 2023., 2023 Abstract Aggregatibacter actinomycetemcomitans is a gram‐negative bacterium associated with periodontal disease and a variety of disseminated extra‐oral infections. Tissue colonization is mediated by fimbriae and non‐fimbriae adhesins resulting in the formation of a sessile bacterial community or biofilm, which confers enhanced resistance to ...
Jake Tristano +3 more
wiley +1 more source