Results 21 to 30 of about 905 (119)
Biological Reviews, Volume 97, Issue 3, Page 1005-1037, June 2022., 2022 ABSTRACT Mammalian innate immunity employs several humoral ‘weapons’ that target the bacterial envelope. The threats posed by the multidrug‐resistant ‘ESKAPE’ Gram‐negative pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are forcing researchers to explore new therapeutic options, including the ...
María Escobar‐Salom +4 more
wiley +1 more source
Cellular Microbiology, Volume 23, Issue 3, March 2021., 2021 Abstract Intracellular bacteria such as Salmonella enterica are confronted with a broad array of defence mechanisms of their mammalian host cells. The ability to sense host cell‐imposed damages, and to mount efficient stress responses are crucial for survival and proliferation of intracellular pathogens.
Marc Schulte +2 more
wiley +1 more source
Role of the Two-Component Regulator CpxAR in the Virulence of Salmonella enterica Serotype Typhimurium [PDF]
Infection and Immunity, 2004 ABSTRACT The CpxAR (Cpx) two-component regulator controls the expression of genes in response to a variety of environmental cues. The Cpx regulator has been implicated in the virulence of several gram-negative pathogens, although a role for Cpx in vivo has not been demonstrated directly.
Humphreys, Sue +7 more
openaire +3 more sources
Indole Sensing Regulator (IsrR) Promotes Virulence Gene Expression in Enteric Pathogens
mBio, 2022 Enteric pathogens such as enterohemorrhagic E. coli (EHEC) and its surrogate murine model Citrobacter rodentium sense indole levels within the gut to navigate its biogeography and modulate virulence gene expression.
Aman Kumar +3 more
doaj +1 more source
Indole contributes to tetracycline resistance via the outer membrane protein OmpN in Vibrio splendidus [PDF]
, 2020 As an interspecies and interkingdom signaling molecule, indole has recently received attention for its diverse effects on the physiology of both bacteria and hosts. In this study, indole increased the tetracycline resistance of Vibrio splendidus.
Guo, Ming +6 more
core +1 more source
Dual Regulation of Phosphatidylserine Decarboxylase Expression by Envelope Stress Responses
Frontiers in Molecular Biosciences, 2021 Bacteria adapt to versatile environments by modulating gene expression through a set of stress response regulators, alternative Sigma factors, or two-component systems.
Yasmine Hassoun +4 more
doaj +1 more source
Copper tolerance in bacteria requires the activation of multiple accessory pathways
Molecular Microbiology, Volume 114, Issue 3, Page 377-390, September 2020., 2020 Copper is essential, but highly toxic. Direct responses of bacteria to excess copper, collectively termed copper homeostasis systems, are well known, but how copper causes toxicity is unclear. This review summarizes how both direct copper homeostasis responses, and indirect accessory stress‐response pathways are essential to resisting copper toxicity ...
Andrea Giachino, Kevin J. Waldron
wiley +1 more source
Role of the CpxAR Two-Component Signal Transduction System in Control of Fosfomycin Resistance and Carbon Substrate Uptake [PDF]
Journal of Bacteriology, 2013 Although fosfomycin is an old antibiotic, it has resurfaced with particular interest. The antibiotic is still effective against many pathogens that are resistant to other commonly used antibiotics. We have found that fosfomycin resistance of enterohemorrhagic Escherichia coli (EHEC) O157:H7 is controlled by the bacterial two-component signal ...
Kumiko, Kurabayashi +4 more
openaire +2 more sources
Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]
, 2013 The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Imamovic, Lejla +1 more
core +2 more sources
Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. [PDF]
, 2017 Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration.
Adler-Abramovich, Lihi +10 more
core +3 more sources