Results 31 to 40 of about 905 (119)

CpxA/R‐Controlled Nitroreductase Expression as Target for Combinatorial Therapy against Uropathogens by Promoting Reactive Oxygen Species Generation

Advanced Science, 2023
The antibiotic resistances emerged in uropathogens lead to accumulative treatment failure and recurrent episodes of urinary tract infection (UTI), necessitating more innovative therapeutics to curb UTI before systematic infection.
Hao Ren, Zixing Zhong, Shuang Zhou, Yiyang Wei, Yujiao Liang, Huiling He, Zijian Zheng, Mengyuan Li, Qian He, Tengfei Long, Xinlei Lian, Xiaoping Liao, Yahong Liu, Jian Sun   +13 more
doaj   +1 more source

Global gene-expression analysis of the response of Salmonella Enteritidis to egg-white exposure reveals multiple egg-white-imposed stress responses [PDF]

, 2017
Chicken egg white protects the embryo from bacterial invaders by presenting an assortment of antagonistic activities that combine together to both kill and inhibit growth. The key features of the egg-white anti-bacterial system are iron restriction, high
Alabdeh, Mariah, Andrews, Simon C., Baron, Florence, Bonnassie, Sylvie, Cochet, Marie-Françoise, Gautier, Michel, Guérin-Dubiard, Catherine, Jan, Sophie, Nau, Françoise   +8 more
core   +2 more sources

ZraP is a periplasmic molecular chaperone and a repressor of the zinc-responsive two-component regulator ZraSR [PDF]

, 2011
The bacterial envelope is the interface with the surrounding environment and is consequently subjected to a barrage of noxious agents including a range of compounds with antimicrobial activity.
Andrea Hall, Appia-Ayme, Bader, Buelow, Cherepanov, Corinne Appia-Ayme, Danese, Datsenko, Delaney, Demeler, DiGiuseppe, Elaine Patrick, Fardini, Fleischer, Gary Rowley, Gemski, Graham, Graham, Hagenmaier, Hoiseth, Houry, Huang, Isaac, Kwon, Leonhartsberger, Merdanovic, Noll, Quan, Raffa, Raivio, Raivio, Rowley, Shiny Rajadurai, Tedin, Thede, Thomas A. Clarke, Uzzau, Zhao, Zhou   +38 more
core   +1 more source

Complex Response of the CpxAR Two-Component System to β-Lactams on Antibiotic Resistance and Envelope Homeostasis in Enterobacteriaceae

Antimicrobial Agents and Chemotherapy, 2020
The Cpx stress response is widespread among Enterobacteriaceae . We previously reported a mutation in cpxA in a multidrug-resistant strain of Klebsiella aerogenes isolated from a patient treated with imipenem.
Muriel Masi, Elizabeth Pinet, Jean-Marie Pagès   +2 more
openaire   +3 more sources

The two‐component system CpxAR is essential for virulence in the phytopathogen bacteria D ickeya dadantii   EC 3937 [PDF]

Environmental Microbiology, 2015
Summary The CpxAR two‐component system is present in many P roteobacteria. It controls expression of genes required to maintain envelope integrity in response to environmental injury.
Sébastien Bontemps‐Gallo, Edwige Madec, Jean‐Marie Lacroix   +2 more
openaire   +1 more source

Functional characterization of a novel outer membrane porin KpnO, regulated by PhoBR two-component system in Klebsiella pneumoniae NTUH-K2044. [PDF]

PLoS ONE, 2012
BACKGROUND: The diffusion of antibiotics through the outer membrane is primarily affected by the porin super family, changes contribute to antibiotic resistance. Recently we demonstrated that the CpxAR two-component signaling system alters the expression
Vijaya Bharathi Srinivasan, Manjunath Venkataramaiah, Amitabha Mondal, Vasanth Vaidyanathan, Tanvi Govil, Govindan Rajamohan   +5 more
doaj   +1 more source

The Expression Levels of Outer Membrane Proteins STM1530 and OmpD, Which Are Influenced by the CpxAR and BaeSR Two-Component Systems, Play Important Roles in the Ceftriaxone Resistance of Salmonella enterica Serovar Typhimurium [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT Significant increases in STM3031, STM1530, and AcrD protein levels and significant decreases in OmpC and OmpD protein levels are present when the ceftriaxone-resistant Salmonella enterica serovar Typhimurium R200 strain is compared with the ceftriaxone-susceptible strain 01-4.
Wensi S, Hu, Hung-Wen, Chen, Rui-Yang, Zhang, Chung-Yi, Huang, Chi-Fan, Shen   +4 more
openaire   +2 more sources

EfeUOB (YcdNOB) is a tripartite, acid‐induced and CpxAR‐regulated, low‐pH Fe²⁺ transporter that is cryptic in Escherichia coli K‐12 but functional in E. coli O157:H7 [PDF]

Molecular Microbiology, 2007
Summary Escherichia coli possesses iron transporters specific for either Fe2+ or Fe3+. Although Fe2+ is far more soluble than Fe3+, it rapidly oxidizes aerobically at pH ≥ 7. Thus, FeoAB, the major Fe2+ transporter of E. coli, operates anaerobically. However, Fe2+ remains stable aerobically under acidic conditions, although a low‐pH Fe2+ importer has ...
Jieni, Cao, Mark R, Woodhall, Javier, Alvarez, Michaël L, Cartron, Simon C, Andrews   +4 more
openaire   +2 more sources

A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis [PDF]

, 2002
Bacteria need dedicated systems that allow appropriate adaptation to the perpetual changes in their environments. In Bacillus subtilis, two HtrA-like proteases, HtrA and HtrB, play critical roles in the cellular response to secretion and heat stresses ...
Bron, Sierd, Darmon, Elise, Devine, Kevin M., Dijl, Jan Maarten van, Kuipers, Oscar P., Masson, Anne, Noone, David   +6 more
core   +3 more sources

Maintaining Integrity Under Stress:Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria [PDF]

, 2019
The Gram-negative bacterial envelope is an essential interface between the intracellular and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the maintenance of this barrier and function to detect and respond to ...
Abe, Acosta, Acosta, Ades, Ahuja, Akiyama, Alba, Altman, Amar, Amy, Appia-Ayme, Appia-Ayme, Arie, Asmar, Audrain, Avican, Baker, Bardwell, Barthel, Bazire, Behrens, Belas, Bernal-Cabas, Bina, Bodelon, Bos, Braun, Buelow, Buist, Bustamante, Button, Carlsson, Carlsson, Chaba, Chaba, Chao, Chassaing, Clemens, Collinet, Collins, Coornaert, Cornelis, Cornelis, Cosma, Crouch, Dalebroux, Dalebroux, Damron, Danese, Danese, Dartigalongue, Darwin, De la Cruz, De la Cruz, De Las Peñas, De Las Peñas, De Wulf, Debnath, Delhaye, Delhaye, DiGiuseppe, DiRita, Douchin, Drummond, Du, Eriksson, Ernst, Evans, Fang Ferric, Fardini, Fardini, Field, Figueroa-Bossi, Flores-Kim, Flores-Kim, Flynn, Friedrich, Frohlich, Fujimoto, Gal-Mor, Gallagher, Gangaiah, Gangaiah, Ge, Gellatly, Ghequire, Giannakopoulou, Gill, Gogol, Govan, Grabenstein, Grabowicz, Grabowicz, Griffiths, Guest, Guisbert, Guo, Guo, Hagan, Hagan, Hayden, Hernday, Heroven, Heroven, Heusipp, Heusipp, Hirano, Holmqvist, Hood, Hooda, Horne, Humphreys, Humphreys, Humphreys, Humphries, Hung, Häse, Höltje, Isaac, Ito, Jennings, Johansen, Jones, Kandler, Kanehara, Kato, Kimkes, Kint, Klein, Klein, Klein, Konovalova, Konovalova, Koronakis, Kovacikova, Kuhn, Kunkle, Kwon, Labandeira-Rey, Labandeira-Rey, Lasaro, LeClerc, Lee, Lee, Lewis, Li, Li, Li, Li, Liu, Liu, Luirink, Macritchie, MacRitchie, Macritchie, Magnet, Mathee, Mathur, McCleary, McDaniel, McDaniel, McGhie, Mellies, Misra, Mitobe, Miyadai, Morris, Muller, Nakayama, Nakayama, Nakayama, Nakayama, Narita, Nevesinjac, O'Loughlin, Obi, Okkotsu, Okuda, Osborne, Otto, Palmer, Pandey, Papenfort, Patel, Pedersen, Petit-Härtlein, Plummer, Pogliano, Potvin, Price, Qiu, Que, Raffa, Raivio, Raivio, Raivio, Raivio, Raivio, Rao, Redford, Redford, Rhodius, Rolhion, Ronnebaumer, Rouvière, Rowley, Rowley, Rowley, Ruiz, Shimizu, Shimohata, Silhavy, Siroy, Sittka, Sklar, Sklar, Skovierova, Slamti, Snyder, Sohn, Song, Song, Southern, Spiess, Spöring, Srikumar, Stankeviciute, Storek, Subramaniam, Sydenham, Szewczyk, Tanaka, Taylor, Taylor, Testerman, Thanikkal, Thomassin, Thomassin, Tobe, Tschauner, Tsirigotaki, Tzeng, Tzeng, Vincent, Vlahou, Vogel, Vogt, Vogt, Vogt, Vogt, Voulhoux, Vuong, Wall, Walsh, Walsham, Weatherspoon-Griffin, Weirich, Wolfe, Wullt, Xie, Yakhnina, Yamamoto, Yamamoto, Yang, Yoon, Yu, Yu, Zhang, Zhou, Zhu, Ünal   +270 more
core   +1 more source