Results 51 to 60 of about 275,126 (317)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Microstructural modelling of creep crack growth from a blunted crack [PDF]
, 1998 The effect of crack tip blunting on the initial stages of creep crack growth is investigated by means of a planar microstructural model in which grains are represented discretely. The actual linking-up process of discrete microcracks with the macroscopic
Giessen, E. van der +4 more
core
Toxicological Sciences, 2004 Phthalate esters impart flexibility to hard plastics, are used as inert ingredients in cosmetics and personal hygiene products, and are ubiquitous environmental contaminants. Finding the underlying molecular mechanism of phthalate-induced testicular injury has been a vision quest of male reproductive toxicologists for many decades.
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
British Journal of General Practice, 2008 I took a moment to listen to his breathing. My heart sank. Even without the aid of a stethoscope, it sounded like stridor and, given his age and past smoking, a bronchial carcinoma until proven otherwise. It had not been an easy trip for my Dad who, accompanied by Mum, had fallen through the system when their first connecting flight from Glasgow had ...
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Weld residual stress effects on fatigue crack growth behaviour of aluminium alloy 2024-T351 [PDF]
, 2008 The interaction between residual stress and fatigue crack growth rate has been investigated in middle tension and compact tension specimens machined from a variable polarity plasma arc welded aluminium alloy 2024-T351 plate.
Liljedahl, CDM +31 more
core +1 more source
Applied Sciences, 2020 The article focuses on the bending problem for a cantilever beam with a straight through-thickness crack, perpendicular to its axis under bending by concentrated force.
Mykhaylo Delyavskyy +2 more
doaj +1 more source
Design parameters of steel fiber concrete beams
Magazine of Civil Engineering, 2021 In the study of steel fiber concrete beams, there are many design parameters that affecting stress-strain state, cracks formation and cracks development, etc. in beams.
Thi My Dung Do, Thanh Quang Khai Lam
doaj +1 more source
, 2000 This paper discusses information technology as political and practical discourse. This repetitive discursive model can be distinguished in global, regional and local contexts and contains an optimistic belief in technology as an independent power that automatically furthers democratic development.
Annelie Ekelin, Pirjo Elovaara
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