Results 71 to 80 of about 338,464 (293)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Three-dimensional crack growth in multi-layered architectures for automotive plain bearings
, 2009 The assessment of shielding and anti-shielding effects on crack growth in multi-layered architectures is achieved using elasto-plastic finite element models.
Burke-Veliz, A. +2 more
core +1 more source
Finding and properly segmenting cracks in images of concrete is a challenging task. Cracks are thin and rough and being air filled do yield a very weak contrast in 3D images obtained by computed tomography. Enhancing and segmenting dark lower-dimensional structures is already demanding.
Tin Barisin +4 more
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
ON CRACK CLOSURE IN FATIGUE CRACK GROWTH
, 1978 A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire +2 more sources
Toxicological Sciences, 2004 Phthalate esters impart flexibility to hard plastics, are used as inert ingredients in cosmetics and personal hygiene products, and are ubiquitous environmental contaminants. Finding the underlying molecular mechanism of phthalate-induced testicular injury has been a vision quest of male reproductive toxicologists for many decades.
openaire +2 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Micromechanisms of short fatigue crack growth in an Al-Si piston alloy [PDF]
, 2014 The short fatigue crack growth behaviour of a model cast aluminium piston alloy has been investigated. This has been achieved using a combination of fatigue crack replication methods at various intervals during fatigue testing and post-mortem analysis of
T.O. Mbuya +3 more
core +1 more source