FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Numerical implementation of the eXtended Finite Element Method for dynamic crack analysis [PDF]
, 2008 A numerical implementation of the eXtended Finite Element Method (X-FEM) to analyze crack propagation in a structure under dynamic loading is presented in this paper.
Pantalé, Olivier +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Effects of graphite nodules on crack growth behaviour of austempered ductile iron [PDF]
, 2007 Austempered ductile iron (ADI) is a candidate material for camshafts, where however, the early stages of fatigue damage are of major concern during service.
Reed, P.A.S., Gao, N., Stokes, B.
core +1 more source
Autocontrol de la agresividad de las usuarias de crack
Ciencias Psicológicas, 2019 A literatura aponta dificuldades no autocontrole da agressividade de mulheres usuárias de crack. No entanto, carecem estudos que expliquem tais dificuldades.
Jéssica Limberger +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Quasi-static crack propagation by Griffith's criterion [PDF]
, 2008 We consider the propagation of a crack in a brittle material along a prescribed crack path and define a quasi-static evolution by means of stationary points of the free energy. We show that this evolution satisfies Griffith's criterion in a suitable form
Negri, Matteo +4 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Development of a Manual Crack Quantification and Automated Crack Measurment System, Project TR-457 Final Report, 2005 [PDF]
, 2005 Final report produced by DOT on development of manual crack quantification and automatic crack measurment ...
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