Results 61 to 70 of about 338,464 (293)
British Journal of General Practice, 2008 I took a moment to listen to his breathing. My heart sank. Even without the aid of a stethoscope, it sounded like stridor and, given his age and past smoking, a bronchial carcinoma until proven otherwise. It had not been an easy trip for my Dad who, accompanied by Mum, had fallen through the system when their first connecting flight from Glasgow had ...
openaire +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Spanish Journal of Agricultural Research, 2019 This study was aimed to find the causes of pick-up destruction of tomato root lumps using X-ray microcomputed tomography, and to identify the pick-up parameters of low root lump destruction.
Hanping Mao +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Development of a Manual Crack Quantification and Automated Crack Measurment System, Project TR-457 Final Report, 2005 [PDF]
, 2005 Final report produced by DOT on development of manual crack quantification and automatic crack measurment ...
core
O crack em um cenário empedrado: articulações entre os discursos jurídico, médico e midiático
Psicologia & Sociedade, 2014 O artigo aborda o surgimento do crack nas metrópoles brasileiras, o grande internamento de seus usuários na última década e a leitura midiática sobre o tema.
Mateus Freitas Cunda +1 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Frontiers in Built Environment, 2020 Although many models for service life predictions have been developed, their application to existing bridges is still not at a satisfactory level. The here presented coupled three-dimensional chemo-hygro-thermo-mechanical (CHTM) model can realistically ...
Marija Kušter Marić +5 more
doaj +1 more source