In situ measurement of fatigue crack opening stresses by nonlinear vibro-acoustic modulation testing
Advances in Mechanical Engineering, 2017 The difficulty of accurately measuring crack closure regions has hindered measurements of opening or closure stresses, and ultrasonic methods have shown great potentialities in evaluating closure area. Many recent researches have confirmed the advantages
Jun Jia +3 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
The effect of external stiffening elements on the fatigue crack growth in Fibre Metal Laminate
, 2007 Fibre Metal Laminates (FML’s) have been developed in the past to increase the fatigue characteristics of laminated aluminium structures by adding fibres in the bond line.
Rodi, Riccardo
core
Corrosion Fatigue Crack Propagation Behaviour of a High Strength Low Alloy Steel in a Synthetic Sea Water Environment. [PDF]
, 1986 The corrosion fatigue crack propagation behaviour of a high strength low alloy steel, N-A-XTRA 70, in a synthetic sea water solution was tested using S. E. N. specimens subjected to a loading frequency of 0.1 Hz and a load ratio of 0.6.
Millar, Peter G.
core
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Modelling and predicting fatigue crack growth behaviour in weld induced residual stress fields [PDF]
, 2011 In the last few decades, new design concepts and manufacture processes have been developed in order to reduce the maintenance and manufacturing costs, and structural weight of aircraft components. The integral metallic structure with welding processes
Servetti, Guido
core
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Residual Stress Effect on Crack Closure in Additively Manufactured Stainless Steels
Super duplex stainless steels (SDSS) are extensively used in oil and gas, marine, and chemical process industries. Recently, wire-arc additive manufacturing (WAAM) has been demonstrated as an attractive method for fabricating near net-shape structural ...
Sales, A., Kotousov, A., Khanna, A.
core +1 more source