Results 81 to 90 of about 9,188 (302)

Fatigue crack growth in notched specimens: a numerical analysis

Fracture and Structural Integrity, 2019
Fatigue crack growth (FCG) is linked to irreversible and non-linear processes happening at the crack tip, which explains different problems observed in the use of da/dN-?K curves. The replacement of ?K by non-linear crack tip parameters, namely the crack
F.V. Antunes, R. Branco, P. Prates, J.D.M. Costa   +3 more
doaj   +3 more sources

Crack Closure Effects on Fatigue Crack Propagation Rates: Application of a Proposed Theoretical Model

Advances in Materials Science and Engineering, 2016
Structural design taking into account fatigue damage requires a thorough knowledge of the behaviour of materials. In addition to the monotonic behaviour of the materials, it is also important to assess their cyclic response and fatigue crack propagation ...
José A. F. O. Correia, Abílio M. P. De Jesus, Pedro M. G. P. Moreira, Paulo J. S. Tavares   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Identification of Relationships between Heat Treatment and Fatigue Crack Growth of αβ Titanium Alloys

Metals, 2019
This study deals with the influence of microstructure on the fatigue crack growth resistance of αβ titanium alloys: Ti-6Al-4V ELI (Extra Low Interstitial) that may compete with the conventional Ti-6Al-4V alloy in the manufacture of high ...
Vincent Renon, Gilbert Henaff, Céline Larignon, Simon Perusin, Patrick Villechaise   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Investigation of the Damage Mechanisms Influencing the Short Crack Behavior of Inconel 625 Under Variable Amplitude Fatigue Loading

Aerospace
Variable amplitude fatigue loading can result in both accelerated and decelerated fatigue damage due to load interaction effects. Short fatigue cracks in particular exhibit a wide range of crack growth behavior due to multiple damage mechanisms ...
Robert Fleishel, Reza Abedi, Stephanie TerMaath   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Controlling fatigue crack paths for crack surface marking and growth investigations

Fracture and Structural Integrity, 2015
While it is well known that fatigue crack growth in metals that display confined slip, such as high strength aluminium alloys, develop crack paths that are responsive to the loading direction and the local microstructural orientation, it is less well ...
S. Barter, P. White, M. Burchill
doaj   +3 more sources

Applications and Life Cycle Assessment of Shape Memory Polyethylene Terephthalate in Concrete for Crack Closure. [PDF]

Polymers (Basel), 2022
Maddalena R, Sweeney J, Winkles J, Tuinea-Bobe C, Balzano B, Thompson G, Arena N, Jefferson T.   +7 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source