Results 61 to 70 of about 69,100 (301)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Effect of Interrupted Ageing and Retrogression-Reageing Treatments on Fatigue Crack Growth with a Single Applied Overload in 7050 Aluminum Alloy [PDF]
Materials Research, 2018 The influences of interrupted ageing and retrogression and re-ageing heat treatments on fatigue crack growth with a single applied overload in 7050 aluminum alloy were investigated.
André Luís Moreira de Carvalho +1 more
doaj +2 more sources
Measurement of crack opening stresses and crack closure stress profiles from heat generation in vibrating cracks [PDF]
, 2008 A method is described to measure crack opening stresses and closure stress profiles of a surface-breaking crack. Vibration is used to generate frictional heat by rubbing crack face asperities.
Jeremy Renshaw +3 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Evaluation of the effect of crack closure on fatigue crack growth of simulated short cracks [PDF]
A test program was performed to determine the influence of crack closure on fatigue crack growth (FCG) rates of short cracks. By use of the standard compact tension specimen, test procedures were devised to evaluate closure loads in the wake of the crack
Fisher, D. M., Telesman, J.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Fatigue crack growth in notched specimens: a numerical analysis
Fracture and Structural Integrity, 2019 Fatigue crack growth (FCG) is linked to irreversible and non-linear processes happening at the crack tip, which explains different problems observed in the use of da/dN-?K curves. The replacement of ?K by non-linear crack tip parameters, namely the crack
F.V. Antunes +3 more
doaj +3 more sources
Advances in Materials Science and Engineering, 2016 Structural design taking into account fatigue damage requires a thorough knowledge of the behaviour of materials. In addition to the monotonic behaviour of the materials, it is also important to assess their cyclic response and fatigue crack propagation ...
José A. F. O. Correia +3 more
doaj +1 more source
Influence of fatigue crack wake length and state of stress on crack closure [PDF]
The location of crack closure with respect to crack wake and specimen thickness under different loading conditions was determined. The rate of increase of K sub CL in the crack wake was found to be significantly higher for plasticity induced closure in ...
Fisher, D. M., Telesman, J.
core +1 more source