Results 51 to 60 of about 69,100 (301)

Plasticity induced crack closure in adhesively bonded joints under fatigue loading [PDF]

, 2015
The mean load of a cyclic loading has a large effect on fatigue crack growth rates in metallic materials and bonded joints. In metallic structures, this effect has been attributed to plasticity-induced crack closure, but little is known about the ...
Donough, M, Gunnion, A, Orifici, A, Wang, C   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Deformation and failure characteristics of weathered granite under uniaxial compression

AIP Advances, 2019
In this paper, we have examined the crack formation of weathered granite by monitoring acoustic emissions (AE) under uniaxial compression. Except for the uniaxial compressive strength (UCS), the thresholds have been determined for crack closure, crack ...
Lingfan Zhang, Duoxing Yang, Zhonghui Chen   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Constant amplitude and post-overload fatigue crack growth behavior in PM aluminum alloy AA 8009 [PDF]

, 1992
A recently developed, rapidly solidified, powder metallurgy, dispersion strengthened aluminum alloy, AA 8009, was fatigue tested at room temperature in lab air.
Blankenship C. P., Dawicke D. S., Dutta V. B., Elber W., Gilman P. S., Hawk J. A., McEvily A. J., Piascik R. S., Rao K. T. V., Raybould D., Ritchie R. O., Vecchio R. S., Venkateswara Rao K. T.   +12 more
core   +2 more sources

ON CRACK CLOSURE IN FATIGUE CRACK GROWTH

, 1978
A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Fatigue crack growth and crack closure in vacuum.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1985
For S35C medium carbon steel and A5083-O aluminum alloy, fatigue crack growth tests were carried out in vacuum and in air under ΔK-increasing-decreasing condition, and crack growth rates and crack closure behavior were investigated in detail. In addition, ΔK constant tests were performed in air-to-vacuum-to-air environment.
m.jono, Song, JH Song, Ji Ho, m.ohgaki
openaire   +2 more sources