Results 121 to 130 of about 186,782 (332)

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez   +10 more
wiley   +1 more source

Plasticity induced crack closure effect on fatigue crack growth

open access: yes, 2018
This study is focused on plasticity induced crack closure effect on fatigue crack propagation. It utilizes finite element method modeling to evaluate the effect of this phenomenon on crack propagation at a series of MT specimen configurations.
Šebík, Marek
core  

Fatigue crack closure

open access: yes, 2021
Työssä käydään läpi väsytyssärön sulkeutumista tutkivaa kirjallisuutta. Kirjallisuuskatsaus pitää sisällään ilmiön historiaa ja havainnollistavan kuvauksen tärkeimmistä väsytyssärön sulkeutumismekanismeista.
Kärkkäinen, Kimmo
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

open access: yesArthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby   +448 more
wiley   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

open access: yesArthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni   +7 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

open access: yesAdvanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt   +8 more
wiley   +1 more source

Laser Powder Bed Fusion of Alumina: Effects of Scanning Strategies on External and Internal Defects

open access: yesAdvanced Engineering Materials, EarlyView.
This study investigates how scanning strategies affect pure alumina in laser powder bed fusion. Linear 45° scanning yields uniform surfaces but high porosity, while the island‐concentric strategy provides higher density with through‐holes favorable for infiltration. Findings highlight pathways toward optimizing defect‐free alumina parts.
Mohamed Abdelmoula   +7 more
wiley   +1 more source

Validation and Veri cation of the Acoustic Emission Technique for Structural Health Monitoring [PDF]

open access: yes, 2013
The performance of the Acoustic Emission (AE) technique was investigated to establish its reliability in detecting and locating fatigue crack damage as well as distinguishing between di erent AE sources in potential SHM applications.
Gagar, Daniel Omatsola
core  

Effect of crack closure on the threshold of micro fatigue crack propagation under mixed mode

open access: yes, 1987
1987-10-31Tests of plane bending, cyclic torsion and their combination are carried out with a stress ratio R=-1, using aged cracked specimens made of carbon steel.
Kitaoka, Seiichiro   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy