Results 101 to 110 of about 58,869 (302)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Modeling of creep-fatigue interaction effects on crack growth at elevated temperatures

open access: yesMATEC Web of Conferences, 2018
The well-known load frequency effect on creep-fatigue crack growth is explained by the interactions between fatigue and creep loading and is quantified using the concept of plasticity-induced crack closure.
Potirniche Gabriel P.
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Simulating infiltration processes into fractured and swelling soils as triggering factors of landslides [PDF]

open access: yes, 2013
The influence of rainfall in triggering landslides is a widely discussed topic in scientific literature. The slope stability of fractured surface soils is often influenced by the soil suction.
Galeandro, A, Simeone, V, Šimunek, J
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Experimental and analytical study of cracks under biaxial fatigue [PDF]

open access: yes, 2016
Most mechanical components experience multi-axial cyclic loading conditions during service. Experimental analysis of fatigue cracks under such conditions is not easy and most works tend to focus more on the simpler but less realistic case of uni-axial ...
Camas, Daniel   +5 more
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Damage characteristics and energy storage evolution law of coal with pressure relief borehole

open access: yesMeitan kexue jishu
In the environment of deep strong mining-induced stress, phenomena such as borehole collapse, closure and compaction are prone to occur in large-diameter pressure relief boreholes in coal seams, and the pressure relief effect shows obvious time-effect ...
Yanchun YIN   +5 more
doaj   +1 more source

Propagation of Fatigue Cracks under Shear Loading Modes II, III and II+III in the Near-Threshold Region [PDF]

open access: yes, 2014
Práce je zaměřena na šíření únavových trhlin v módech II, III a II + III v prahové oblasti v kovových materiálech. Byly provedeny experimenty pro ARMCO železo, titan, nikl a austenitickou ocel na třech druzích vzorků pro zatěžování trhliny ve smykových ...
Vojtek, Tomáš
core  

Short crack initiation and growth at 600 °C in notched specimens of Inconel718

open access: yes, 2003
The natural initiation and growth of short cracks in Inconel®718 U-notch specimens has been studied at 600 °C in air. U notches were introduced through broaching, and hardness traces and optical microscopy on cross-sections through the U notch broaching ...
Connolley, T.   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy