Results 81 to 90 of about 9,782,361 (275)

Mixed-mode thermo elastic delamination fracture behavior of composite skin stiffener containing interface delamination

Journal of Materials Research and Technology, 2019
This paper presents the thermo-elastic effect on materials having anisotropic behavior and stresses developed due to residual temperature on interlaminar delamination fracture characteristics of composite skin stiffener.
Saumya Shah, Pardeep Kumar, S.K. Panda, Sandeep Kumar   +3 more
doaj   +1 more source

Crack closure and retardation effects – experiments and modelling

Procedia Structural Integrity, 2017
Abstract The design of cyclically loaded components is in many cases carried out on the basis of experiments on small-scale laboratory specimens. In this approach, many effects such as load ratio, residual stresses and short crack growth are taken into account and described in a computational crack growth model.
J. Maierhofer, H.-P. Gänser, R. Pippan
openaire   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Innovative reinforcement techniques for 3D-printed concrete: The impact of shape memory alloys on flexural strength and crack mitigation

Next Materials
The flexural performance (FP) of 3D Printed Concrete (3DPC) remains a challenge due to its limitations in tensile strength and resistance to cracking. To address these issues, innovative reinforcement materials, such as Shape Memory Alloys (SMAs), which ...
Ronak Motiani, Saha Keunang Sylvain, Sejal P. Dalal, Jay Vora, Rakesh Chaudhari   +4 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Influence of roughness on the mechanical response of rock-like specimens with nonpersistent joints under uniaxial compression based on joint deformation analysis

Underground Space
Joint deformation is a key factor controlling the mechanical behavior of discontinuous rock strata under changing stress conditions, including dominating the elastic deformation in near-surface excavations and serving as a major component of settlement ...
Hong Yin, Zehui Gao, Yulong Shao, Shuhong Wang, Jae-Joon Song, Ye Wang, Jineon Kim, Shan Guo   +7 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Characterization of Microstructural Effects on Fatigue Crack Closure

, 1991
The growth of a fatigue crack is modified by the development of contacts between the crack faces1,2 creating shielding and thus canceling a portion of the applied load. These contacts develop through a number of mechanisms, including plastic deformation, sliding of the faces with respect to each other and the creation and collection of debris such as ...
Rehbein, David, Barnard, Dan, Buck, Otto
openaire   +3 more sources