Results 71 to 80 of about 58,869 (302)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Numerical Model of Plastic Deformation on Cracked Surface under Repeated Pneumatic Impact
Advances in Materials Science and Engineering, 2018 Crack-closure treatment through repeated impact is supposed to be an effective, economical way to extend the fatigue remaining life for fatigue-affected structures with less damage.
Zhiyuan YuanZhou +3 more
doaj +1 more source
Fatigue crack propagation behavior of old puddle iron including crack closure effects
Procedia Structural Integrity, 2016 AbstractIn this paper the fatigue crack growth behavior in structural components from the old 19th century structures (e.g. bridges) has been investigated. The delivered material for investigation was extracted from a beam made of puddled iron, commonly used in 19th century. The obtained results from several ancient railway metallic bridges (located in
Lesiuk, Grzegorz +3 more
openaire +1 more source
The effect of thickness on fatigue crack propagation in 7475-T731 aluminum alloy sheet [PDF]
Tests were conducted on three thicknesses of 7475-T731 aluminum alloy sheet to investigate the effect of thickness on fatigue crack propagation under constant amplitude loading conditions and on retardation following a single peak overload.
Daiuto, R. A., Hillberry, B. M.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
RESEARCH ON FATIGUE CRACK PROPAGATION OF LEAF SPRING UNDER VARIABLE AMPLITUDE LOAD
Jixie qiangdu, 2021 The prediction model of leaf springs fatigue crack growth under variable amplitude loads is mainly Schütz phenomenological model. However, the effect of the crack closure effect on fatigue crack propagation and the relationship between the parameters and
XIANG YuXia, WU ZhiFei
doaj
Environmental fatigue in aluminum-lithium alloys [PDF]
Aluminum-lithium alloys exhibit similar environmental fatigue crack growth characteristics compared to conventional 2000 series alloys and are more resistant to environmental fatigue compared to 7000 series alloys.
Piascik, Robert S.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Influence of load interactions on crack growth as related to state of stress and crack closure [PDF]
Fatigue crack propagation (FCP) after an application of a low-high loading sequence was investigated as a function of specimen thickness and crack closure.
Telesman, J.
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source