Results 71 to 80 of about 9,782,361 (275)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Thermal effect of plastic dissipation at the crack tip on the stress intensity factor under cyclic loading [PDF]

, 2011
The authors acknowledge Arts et Métiers ParisTech and Fondation Arts et Métiers for the financial support of Paul C. Paris’ stay at LAMEFIP in 2009. The encouragement of Prof. Ivan Iordanoff, Director of LAMEFIP, is acknowledged with thanks.
PARIS, Paul C., T. Palin-Luc, PARIS, Paul Croce, PALIN-LUC, Thierry, RANC, Nicolas, P.C. Paris, PALIN LUC, Thierry, N. Ranc, Paris, Paul   +8 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An inverse method for evaluating weld residual stresses via fatigue crack growth test data [PDF]

, 2010
This paper presents an inverse method for calculating the thermal residual stresses in welded specimens via measured fatigue crack growth rates. Firstly, fracture-mechanics superposition law has been used to extract the stress intensity factor due to ...
Rui Bao, Xiang Zhang, Bao, Rui, Zhang, Xiang   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Effect of compressive loads on plasticity induced crack closure [PDF]

, 2015
Compressive stresses play an important role on tension-compression fatigue which can be attributed to plasticity induced crack closure (PICC). The objective here is to study numerically the effect of compressive stresses on PICC and to discuss the ...
Branco, R., Correia, Luís M., Correia, L., Antunes, F. V., Antunes, F.V., Camas, D.   +5 more
core   +1 more source

Effect of yield stress on fatigue crack growth

Fracture and Structural Integrity, 2019
. Fatigue crack growth (FCG) depends on loading, geometry and also material properties. Since FCG is supposedly linked to crack tip plastic deformation, material’s yield stress, Y0, is an important parameter.
Fernando Ventura Antunes, Micael Frias Borges, Pedro Prates, Ricardo Branco, Marta Oliveira   +4 more
doaj   +3 more sources

EFFECTS OF CRACK MORPHOLOGY AND CLOSURE ON ULTRASONIC RESPONSE

AIP Conference Proceedings, 2009
Progress is reported on the development of tools for the study of the influence of crack morphology and closure on ultrasonic inspection response. An in‐situ phased array sector scan is described for the monitoring of crack responses under load, and results are presented showing the anticipated dependence of signal amplitude on crack closure.
R. A. Roberts, Donald O. Thompson, Dale E. Chimenti   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source