Results 51 to 60 of about 3,575 (257)

An Integral Formulation of Two-Parameter Fatigue Crack Growth Model

Advances in Materials Science and Engineering, 2018
A two-parameter fatigue crack growth algorithm in integral form is proposed, which can describe the continuous crack growth process over the time period.
Jianguo Wu, Shan Jiang, Wei Zhang, Zili Wang   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

3D-VCCT based fracture analysis method for gas pipelines with multiple cracks

Natural Gas Industry B, 2019
The current national criteria cannot accurately reflect the multi-crack interference effect of defective gas pipelines, and thus result in conservative assessment results.
Anlin Yao, Wenbo He, Taolong Xu, Hongye Jiang, Dongfang Gu   +4 more
doaj   +1 more source

Some experimental observations of crack-tip mechanics with displacement data [PDF]

Fracture and Structural Integrity, 2015
In the past two decades, crack-tip mechanics has been increasingly studied with full-field techniques. Within these techniques, Digital Image Correlation (DIC) has been most widely used due to its many advantages, to extract important crack-tip ...
M. Mokhtari, P. Lopez-Crespo, B. Moreno, M. Zanganeh   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Numerical Model of Plastic Deformation on Cracked Surface under Repeated Pneumatic Impact

Advances in Materials Science and Engineering, 2018
Crack-closure treatment through repeated impact is supposed to be an effective, economical way to extend the fatigue remaining life for fatigue-affected structures with less damage.
Zhiyuan YuanZhou, Bohai Ji, Tong Sun, Zhi Ye   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

RESEARCH ON FATIGUE CRACK PROPAGATION OF LEAF SPRING UNDER VARIABLE AMPLITUDE LOAD

Jixie qiangdu, 2021
The prediction model of leaf springs fatigue crack growth under variable amplitude loads is mainly Schütz phenomenological model. However, the effect of the crack closure effect on fatigue crack propagation and the relationship between the parameters and
XIANG YuXia, WU ZhiFei
doaj