Results 61 to 70 of about 58,869 (302)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
An Integral Formulation of Two-Parameter Fatigue Crack Growth Model
Advances in Materials Science and Engineering, 2018 A two-parameter fatigue crack growth algorithm in integral form is proposed, which can describe the continuous crack growth process over the time period.
Jianguo Wu +3 more
doaj +1 more source
A boundary integral equation method in the frequency domain for cracks under transient loading [PDF]
, 2016 Acknowledgments The financial support of the German Academic Exchange Service (DAAD), Engineering and Physical Sciences Research Council (EPSRC) and Advanced Research Collaboration (ARC) Programme (funded by the British Council and DAAD) is gratefully ...
Guz, I. A. +4 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
3D-VCCT based fracture analysis method for gas pipelines with multiple cracks
Natural Gas Industry B, 2019 The current national criteria cannot accurately reflect the multi-crack interference effect of defective gas pipelines, and thus result in conservative assessment results.
Anlin Yao +4 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Strain-energy release rate analysis of a laminate with a postbuckled delamination [PDF]
The objectives are to present the derivation of the new virtual crack closure technique, evaluate the accuracy of the technique, and finally to present the results of a limited parametric study of laminates with a postbuckled delamination.
Shivakumar, K. N., Whitcomb, John D.
core +1 more source
Correlation between the pivot node concept and fatigue crack closure [PDF]
, 2018 The study of fatigue crack growth has been commonly done by means of bi-dimensional models and assuming a homogeneous behaviour through the thickness. According to the specimen thickness, a state of plane stress or plane strain is presumed.
Camas, Daniel +2 more
core