Results 41 to 50 of about 9,782,361 (275)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Fatigue crack growth behaviour and life prediction for 2324-T39 and 7050-T7451 aluminium alloys under truncated load spectra [PDF]
, 2010 This paper presents a study of crack growth behaviour in aluminium alloys 2324- T39 and 7050-T7451 subjected to flight-by-flight load spectra at different low- stress truncation levels. Crack branching was observed in the higher truncation levels for the
Bao, Rui, Zhang, Xiang
core +1 more source
Metals, 2019 This study deals with the influence of microstructure on the fatigue crack growth resistance of αβ titanium alloys: Ti-6Al-4V ELI (Extra Low Interstitial) that may compete with the conventional Ti-6Al-4V alloy in the manufacture of high ...
Vincent Renon +4 more
doaj +1 more source
Lateral Impact Response of Concrete-Filled Square Steel Tubes with Local Defects
Buildings, 2022 A numerical model of 84 high-strength concrete-filled square steel tubular columns (HSCFST) with local defects is developed using ABAQUS. The effects of parameters such as crack angle, crack length, impact surface and impact energy on the impact ...
Yulin Wang +3 more
doaj +1 more source
Simulation of crack closure effect on cracked beam vibrations
Engineering Fracture MechanicsVibrations of beams containing cracks are usually investigated by using open or breathing crack models. Neither one of these approaches considers the plasticity induced crack closure (PICC) phenomena which occurs in fatigue crack growth. In this study, PICC is integrated into the vibration analysis of a cracked beam.
Dağhan Günhan +2 more
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Closure Effect of I + II Mixed-mode Crack for EA4T Axle Steel
Chinese Journal of Mechanical EngineeringThe crack-closure effect is a crucial factor that affects the crack growth rate and should be considered in simulation analysis and testing. A mixed-mode I + II loading fatigue crack growth test was performed using EA4T axle steel specimens.
Shuancheng Wang +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source