Results 41 to 50 of about 58,869 (302)

Lateral Impact Response of Concrete-Filled Square Steel Tubes with Local Defects

Buildings, 2022
A numerical model of 84 high-strength concrete-filled square steel tubular columns (HSCFST) with local defects is developed using ABAQUS. The effects of parameters such as crack angle, crack length, impact surface and impact energy on the impact ...
Yulin Wang, Shan Gao, Youchun Xu, Fangyi Li   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Identification of Relationships between Heat Treatment and Fatigue Crack Growth of αβ Titanium Alloys

Metals, 2019
This study deals with the influence of microstructure on the fatigue crack growth resistance of αβ titanium alloys: Ti-6Al-4V ELI (Extra Low Interstitial) that may compete with the conventional Ti-6Al-4V alloy in the manufacture of high ...
Vincent Renon, Gilbert Henaff, Céline Larignon, Simon Perusin, Patrick Villechaise   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Closure Effect of I + II Mixed-mode Crack for EA4T Axle Steel

Chinese Journal of Mechanical Engineering
The crack-closure effect is a crucial factor that affects the crack growth rate and should be considered in simulation analysis and testing. A mixed-mode I + II loading fatigue crack growth test was performed using EA4T axle steel specimens.
Shuancheng Wang, Bing Yang, Shuwei Zhou, Jian Li, Shoune Xiao   +4 more
doaj   +1 more source

Permanent indentation characterization for low-velocity impact modelling using three-point bending test [PDF]

, 2013
This paper deals with the origin of permanent indentation in composite laminates subjected to low-velocity impact. The three-point bending test is used to exhibit a non-closure of matrix crack which is assumed as a cause of permanent indentation ...
Bouvet, Christophe, Hongkarnjanakul, Natthawat, Miranda, Arturo, Rivallant, Samuel   +3 more
core   +3 more sources

First large scale application with self-healing concrete in Belgium : analysis of the laboratory control tests [PDF]

, 2020
Due to the negative impact of construction processes on the environment and a decrease in investments, there is a need for concrete structures to operate longer while maintaining their high performance.
Caspeele, Robby, De Belie, Nele, Gruyaert, Elke, Van Mullem, Tim   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Development of a fretting-fatigue mapping concept: The effect of material properties and surface treatments [PDF]

, 2009
Fretting-fatigue induced by combined localized cyclic contact motion and external bulk fatigue loadings may result in premature and dramatic failure of the contacting components.
Araújo, Araújo, Bueckner, Crossland, Dang Van, Dini, El Haddad, Fouvry, Fouvry, Fouvry, Fouvry, Fouvry, Fouvry, Fouvry, Giannakopoulos, Hills, Hills, Hills, Johnson, K. Kubiak, Kitagawa, Kubiak, McDiarmid, Mindlin, Mugadu, Nowell, Nowell, Proudhon, S. Fouvry, Szolwinski, Taylor, Waterhouse, Zhou   +32 more
core   +1 more source