Results 91 to 100 of about 186,782 (332)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Micromechanical modeling of brittle damage in composite materials: primary anisotropy, induced anisotropy and opening-closure effects [PDF]
, 2012 Inelastic deformation of various brittle materials such as concrete, rocks or composites has been widely explained by the existence, nucleation and growth of microcracks.
Welemane, Hélène +4 more
core
Journal of Materials Research and Technology, 2019 This paper presents the thermo-elastic effect on materials having anisotropic behavior and stresses developed due to residual temperature on interlaminar delamination fracture characteristics of composite skin stiffener.
Saumya Shah +3 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The effect of external stiffening elements on the fatigue crack growth in Fibre Metal Laminate
, 2007 Fibre Metal Laminates (FML’s) have been developed in the past to increase the fatigue characteristics of laminated aluminium structures by adding fibres in the bond line.
Rodi, Riccardo
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Numerical Modelling of Fatigue Crack Closure
, 2021 This Ph.D. thesis was written under the supervision of Assoc. prof. Pavel Hutař, Ph.D., and Assoc. prof. Luboš Náhlík, Ph.D. The thesis is focused on the effect of plasticity induced crack closure, its characteristic and ways of numerical modelling ...
Oplt, Tomáš
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Next MaterialsThe flexural performance (FP) of 3D Printed Concrete (3DPC) remains a challenge due to its limitations in tensile strength and resistance to cracking. To address these issues, innovative reinforcement materials, such as Shape Memory Alloys (SMAs), which ...
Ronak Motiani +4 more
doaj +1 more source
Crack closure and retardation effects – experiments and modelling
Procedia Structural Integrity, 2017 Abstract The design of cyclically loaded components is in many cases carried out on the basis of experiments on small-scale laboratory specimens. In this approach, many effects such as load ratio, residual stresses and short crack growth are taken into account and described in a computational crack growth model.
J. Maierhofer, H.-P. Gänser, R. Pippan
openaire +1 more source