Results 91 to 100 of about 58,869 (302)

Effect of additional heat treatment of 2024-T3 on the growth of fatigue crack in air and in vacuum [PDF]

In order to determine the influence of ductility on the fatigue crack growth rate of aluminum alloys, fatigue tests were carried out on central notched specimens of 2024-T3 and 2024-T8 sheet material.
Louwaard, E. P.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Towards the understanding of variable amplitude fatigue [PDF]

, 2015
Fatigue life estimation is of high importance during the design stage of a machine or component. Basic fatigue calculations are made based on the use of an S-N curve. As far as constant amplitude loads are applied, this approach works well. However, most
Chhith, Saosometh, De Waele, Wim, Micone, Nahuel   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Innovative reinforcement techniques for 3D-printed concrete: The impact of shape memory alloys on flexural strength and crack mitigation

Next Materials
The flexural performance (FP) of 3D Printed Concrete (3DPC) remains a challenge due to its limitations in tensile strength and resistance to cracking. To address these issues, innovative reinforcement materials, such as Shape Memory Alloys (SMAs), which ...
Ronak Motiani, Saha Keunang Sylvain, Sejal P. Dalal, Jay Vora, Rakesh Chaudhari   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Influence of roughness on the mechanical response of rock-like specimens with nonpersistent joints under uniaxial compression based on joint deformation analysis

Underground Space
Joint deformation is a key factor controlling the mechanical behavior of discontinuous rock strata under changing stress conditions, including dominating the elastic deformation in near-surface excavations and serving as a major component of settlement ...
Hong Yin, Zehui Gao, Yulong Shao, Shuhong Wang, Jae-Joon Song, Ye Wang, Jineon Kim, Shan Guo   +7 more
doaj   +1 more source

Variables controlling fatigue crack growth of short cracks [PDF]

A study was conducted to evaluate the roles of crack closure and microstructure in the fatigue growth of short cracks. Testing was performed at R ratios of 0.1, 0.5, and 0.7.
Fisher, D. M., Holka, D., Telesman, J.
core   +1 more source

Temperature and load-ratio dependent fatigue-crack growth in the CrMnFeCoNi high-entropy alloy [PDF]

, 2019
Multiple-principal element alloys known as high-entropy alloys have rapidly been gaining attention for the vast variety of compositions and potential combinations of properties that remain to be explored. Of these alloys, one of the earliest, the ‘Cantor
George, EP, Gludovatz, B, Laplanche, G, Ritchie, RO, Thurston, KVS, Yu, Q   +5 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source