Results 41 to 50 of about 46,341 (265)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Knowledge base system (KBS) applied on corrosion damage assessment on metallic structure pipes

Heliyon, 2018
This paper aims to outline a proposed knowledge base system (KBS) for the assessment of corrosive damage on metallic pipe conduits. KBS is developed by using two information sources available for assessing the corrosive damage of pipes which are mainly ...
Nabil Cheriet, Nacer Eddine Bacha, Abdelhak Skender   +2 more
doaj   +1 more source

Seismic Response and Damage Analysis of Shield Tunnel with Lateral Karst Cavity under Oblique SV Waves

Buildings, 2023
The dynamic effects of the lateral karst cavity on the shield tunnels under different incident angles of seismic waves are investigated by numerical analysis in this paper, based on the Dalian Metro Line 5 project.
Mingda Li, Kang Meng, Jing Zhou
doaj   +1 more source

Damage identification in a concrete beam using curvature difference ratio [PDF]

, 2011
Previous studies utilising changes in mode shape or curvature to locate damage rely on the fact that the greatest change occurs around the defect. However, in concrete beams this fact is undermined due to the nature of the defect as distributed multi ...
, Ali A Al-Ghalib, Bayissa W, Farrar C, Fouad A Mohammad, John Chilton, Mujib Rahman, Owen J, Salawu O S, Stubbs N, Zhang Z   +10 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A New Approach for Severity Estimation of Transversal Cracks in Multi-layered Beams

Latin American Journal of Solids and Structures
Nowadays, the damage severity evaluation in mechanical structures is mostly performed by analyzing the natural frequency shift. The non-isotropic materials, as the multi-layered ones, are wide-spread in industrial applications, due to their interesting ...
Gilbert-Rainer Gillich, Nuno M. M. Maia, Ion-Cornel Mituletu, Marius Tufoi, Vasile Iancu, Zoltan Korka   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

AI-based damage detection in prestressed concrete beams: a vision-integrated deep learning framework for crack localization and severity classification

Advances in Bridge Engineering
Aging prestressed concrete (PC) structures, particularly those utilizing unbonded tendons, are susceptible to long-term deterioration mechanisms such as creep, shrinkage, and prestress loss, which manifest in complex damage forms including surface ...
Thanh Q. Nguyen, Phuong Phan-Vu, Phuoc T. Nguyen   +2 more
doaj   +1 more source

Damage Detection in Post-Tensioned Slab Using 2D Wavelet Transforms [PDF]

Journal of Rehabilitation in Civil Engineering, 2017
Earthquake force, loading more than structural capacity, cracking, material fatigue, and other unpredicted events are undeniable in the structure life cycle in order that environmental conditions of the structure would be changed and treats health ...
Seyed Rohollah Hoseini Vaez, Ehsan Dehghani, Vahid Babaei   +2 more
doaj   +1 more source