Results 61 to 70 of about 46,341 (265)

Fracture Mechanics Characterization of an AnisotropicGeomaterial [PDF]

, 2012
Argillites are considered worldwide as potential host rock for high level radioactive waste given the low permeability and strong adsorption potential.
Barpi, Fabrizio, Cravero, Masantonio, Fidelibus, Corrado, Iabichino, Giorgio, Valente, Silvio   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Continued Field Evaluation of Precutting for Maintaining Asphalt Concrete Pavements with Thermal Cracking [PDF]

, 2017
In continuation of a previously completed project entitled Evaluate Presawn Transverse Thermal Cracks for Asphalt Concrete Pavement, this project was a further effort to understand important variables in the thermal cracking process through continued ...
Liu, Jenny, McHattie, Robert, Zhao, Sheng   +2 more
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

DAEENet: A novel Dual Attention based Edge Enhanced network for asphalt pavement deterioration detection and segmentation

Case Studies in Construction Materials
Accurate identification of asphalt pavement deterioration is essential for ensuring road safety and optimizing infrastructure maintenance. Traditional methods for detecting pavement distress are often inefficient, time-consuming, labor-intensive, and ...
Andrew Abraham P., Jefferey Joshua Thomas J., Hemanth K., Vasugi K., Sanjeev Kumar, Aravindkumar Sekar   +5 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

On the potential of aerodynamic pressure measurements for structural damage detection [PDF]

Wind Energy Science
This study investigates the potential of using aerodynamic pressure time series measurements to detect structural damage in elastic, aerodynamically loaded structures.
P. Franz, I. Abdallah, G. Duthé, J. Deparday, A. Jafarabadi, A. Jafarabadi, X. Jian, M. von Danwitz, A. Popp, A. Popp, S. Barber, E. Chatzi   +11 more
doaj   +1 more source

Development of probability of detection data for structural health monitoring damage detection techniques based on acoustic emission [PDF]

, 2013
Structural Health Monitoring (SHM) techniques have been developed as a cost effective alternative to currently adopted Non-Destructive Testing (NDT) methods which have well understood levels of performance. Quantitative performance assessment, as used in
Foote, Peter, Gagar, Daniel, Irving, Phil E., Jennions, Ian K., McFeat, Jim, Read, Ian   +5 more
core