Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Crack image detection based on fractional differential and fractal dimension
In civil engineering, crack detection using image processing has gained much attention among researchers and transportation agencies. As the crack image often presents a fuzzy boundary and random shape, it is difficult to achieve satisfactory detection ...
Ting Cao +3 more
doaj +1 more source
Robust surface crack detection with structure line guidance
Crack detection plays a pivotal role in civil engineering applications, where vision-based methods find extensive use. In practice, crack images are sourced from Unmanned Aerial Vehicles (UAV) and handheld photography, and the balance between the ...
Yongjun Zhang +6 more
doaj +1 more source
Comparison of the crack pattern in accelerated corrosion tests and in finite elements simulations [PDF]
In this work, the crack pattern obtained in accelerated corrosion tests is compared to the one obtained in numerical simulations for reinforced steel concrete samples.
Planas Rosselló, Jaime +2 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Quantitative Detection of Cracks in Steel Using Eddy Current Pulsed Thermography
Small cracks are common defects in steel and often lead to catastrophic accidents in industrial applications. Various nondestructive testing methods have been investigated for crack detection; however, most current methods focus on qualitative crack ...
Zhanqun Shi +4 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
An improved U-Net model for concrete crack detection
Crack detection plays an important role in disease assessment of concrete buildings. However, factors such as complex background, irregular edge, and the real-time and accuracy requirement also make crack detection a challenging task. Aiming at the above
Chenglong Yu +4 more
doaj +1 more source
Non-contact ultrasonic detection of angled surface defects [PDF]
Non-destructive testing is an important technique, and improvements are constantly needed. Surface defects in metals are not necessarily confined to orientations normal to the sample surface; however, much of the previous work investigating the ...
Clough, A. R. +3 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source

