Results 101 to 110 of about 231,658 (310)

Growth of surface and corner cracks in beta-processed and mill-annealed Ti-6Al-4V [PDF]

open access: yes
Empirical stress-intensity expressions were developed to relate the growth of cracks from corner flaws to the growth of cracks from surface flaws. An experimental program using beta-processed Ti-6Al-4V verified these expressions for stress ratios, R ...
Bell, P. D.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Constraint effect on corrosion fatigue crack growth behavior of A100 ultrahigh strength steel

open access: yesJournal of Aeronautical Materials
Ultrahigh strength steel has been widely used to manufacture aircraft landing gear and other load-bearing structures,which is prone to corrosion fatigue failure when serving in harsh marine environment.
LI Yizhe   +4 more
doaj   +1 more source

A Simple Numerical Simulation of Crack Growth Rate

open access: yesProcedia Engineering, 2012
AbstractAccording to the classical theory of damage and fracture mechanics a simple damage model is established and a method of stress intensity calculation is given. After comparison of the results, which are obtained from the numerical simulation and experiment with ADB610, it's clear that the numerical method is available.
Liu, Guoshou, Wang, Shiyue, Yang, Xijie
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A Unified Equation for Predicting Crack Growth in Rubber Composites Across All Crack Growth Rates

open access: yesPolymers
The relationship between tearing energy and crack growth rates in elastomers is typically divided into three regions—slow crack growth, fast crack growth, and a transitional region—each described by separate power law relationships, requiring six variables to fully characterize the behavior.
Aaron M. Duncan   +4 more
openaire   +2 more sources

Measurement and analysis of critical crack tip processes during fatigue crack growth [PDF]

open access: yes
The mechanics of fatigue crack growth under constant-amplitudes and variable-amplitude loading were examined. Critical loading histories involving relatively simple overload and overload/underload cycles were studied to provide a basic understanding of ...
Davidson, D. L.   +2 more
core   +1 more source

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