Results 91 to 100 of about 9,692,815 (237)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Study of Fatigue Crack Growth in Superalloy Based on Acoustic Emission K-Entropy
MetalsAcoustic emission (AE) technology was used to monitor the fatigue crack growth process of superalloy. The analysis results show that both the cumulative values and the K-entropy values of AE parameters have good correspondences with the three stages ...
Ting Jing, Yang Yu, Qiang Liu
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
RESEARCH ON FATIGUE CRACK PROPAGATION OF LEAF SPRING UNDER VARIABLE AMPLITUDE LOAD
Jixie qiangdu, 2021 The prediction model of leaf springs fatigue crack growth under variable amplitude loads is mainly Schütz phenomenological model. However, the effect of the crack closure effect on fatigue crack propagation and the relationship between the parameters and
XIANG YuXia, WU ZhiFei
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Constraint Aspects of the Evaluation of Fatigue Test Results in Paris Region
Communications, 2006 The growth of the fatigue crack is dependent on the crack growth resistance of the material as a bulk property. The fatigue crack growth properties of a material are usually described by the correlation between a crack propagation rate, and a ...
Zdenek Knesl +2 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Surface Crack Shape Evolution Modelling using an RMS SIF approach [PDF]
, 2010 The majority of fatigue cracks in thick plate and tubular sections in structural components are two-dimensional surface cracks having significant propagation lives before becoming critical.
Han, S. K. +2 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Study on crack propagation of 42CrMo
Metalurgija, 2019 For the fatigue failure of 42CrMo, the tensile test was performed on the CT specimen at different load ratios using a fatigue tensile tester. Data on the fatigue crack growth rate of the material and the crack tip factor were obtained.
W. C. Pei +4 more
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