Results 71 to 80 of about 9,692,815 (237)

Effects of microstructure on room temperature fatigue crack initiation and short crack propagation in Udimet 720Li Ni-base superalloy

open access: yes, 2008
An assessment of the effects of microstructure on room temperature fatigue crack initiation and short crack propagation in a Ni-base superalloy is presented.
Pang, H.T., Reed, P.A.S.
core   +1 more source

Corrosion Fatigue of Austenitic Stainless Steels for Nuclear Power Engineering

open access: yesMetals, 2016
Significant structural steels for nuclear power engineering are chromium-nickel austenitic stainless steels. The presented paper evaluates the kinetics of the fatigue crack growth of AISI 304L and AISI 316L stainless steels in air and in corrosive ...
Irena Vlčková   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Effect of Notches on Fatigue Crack Initiation and Early Propagation Behaviors of a Ni-Based Superalloy at Elevated Temperatures

open access: yesMetals
The role of notch stress and surface defects on fatigue crack initiation and small-crack propagation behavior has been investigated using groove simulation specimens.
Zuopeng Zhao, Xuteng Hu, Zhiwei Guo
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

EXPERIMENT STUDY ON CRACK GROWTH RATE OF ADB610 STEEL UNDER DIFFERENT STRESS RATIOS

open access: yesJixie qiangdu, 2016
The test of the fatigue crack growth rate under five stress ratios( R = 0. 1,0. 2,0. 3,0. 4 and 0. 5) is completed used the compact tensile specimen. The test data are processed by using incremental polynomial method and the expressions and curves of ...
WEI Long   +3 more
doaj  

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