Results 71 to 80 of about 25,127 (264)

Simulation of Crack Growth Rate in Martensitic Steel

Journal of Applied Sciences, 2007
This research used the stress intensity factor with rate of crack growth per cycle to model and simulate the crack growth in martensitic steel in air environment. The basic parameter used were da/dN and ΔK, log (da/dN) was analyzed against log ΔK and a regression analysis using data from log (da/dN) vs log (ΔK) was carried out and the outcome employed ...
Odukwe, O. A., Ajayi, O. O., Oluwadare, G. O.   +2 more
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Effect of gradient of stress intensity factor at a crack tip on fatigue crack growth and correction method for the effect

Nihon Kikai Gakkai ronbunshu, 2014
The stress intensity factor can be applied as an evaluation parameter of crack growth under small-scale yielding conditions. Moreover, the stress intensity factor corrected by the plastic zone correction can potentially be used as an evaluation parameter
Sho KAWATSU, Tetsuo YASUOKA, Yoshihiro MIZUTANI, Akira TODOROKI, Yoshiro SUZUKI   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Simple Numerical Simulation of Crack Growth Rate

Procedia Engineering, 2012
AbstractAccording to the classical theory of damage and fracture mechanics a simple damage model is established and a method of stress intensity calculation is given. After comparison of the results, which are obtained from the numerical simulation and experiment with ADB610, it's clear that the numerical method is available.
Liu, Guoshou, Wang, Shiyue, Yang, Xijie
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

RESEARCH ON FATIGUE CRACK PROPAGATION OF LEAF SPRING UNDER VARIABLE AMPLITUDE LOAD

Jixie qiangdu, 2021
The prediction model of leaf springs fatigue crack growth under variable amplitude loads is mainly Schütz phenomenological model. However, the effect of the crack closure effect on fatigue crack propagation and the relationship between the parameters and
XIANG YuXia, WU ZhiFei
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Study of Fatigue Crack Growth in Superalloy Based on Acoustic Emission K-Entropy

Metals
Acoustic emission (AE) technology was used to monitor the fatigue crack growth process of superalloy. The analysis results show that both the cumulative values and the K-entropy values of AE parameters have good correspondences with the three stages ...
Ting Jing, Yang Yu, Qiang Liu
doaj   +1 more source