Results 61 to 70 of about 25,058 (265)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
EXPERIMENT STUDY ON CRACK GROWTH RATE OF ADB610 STEEL UNDER DIFFERENT STRESS RATIOS
Jixie qiangdu, 2016 The test of the fatigue crack growth rate under five stress ratios（ R = 0. 1,0. 2,0. 3,0. 4 and 0. 5） is completed used the compact tensile specimen. The test data are processed by using incremental polynomial method and the expressions and curves of ...
WEI Long +3 more
doaj
Investigation of the Combined Influence of Temperature and Humidity on Fatigue Crack Growth Rate in Al6082 Alloy in a Coastal Environment. [PDF]
Materials (Basel), 2023 Alqahtani I, Starr A, Khan M.
europepmc +1 more source
The Influence of In-Plane Constraints on Fatigue Crack Growth Rate
Advances in Science and Technology Research JournalThe geometry of structural members can influence the fatigue crack growth rate. In the paper, the T-stress depending on the element's geometry is used to quantify the effect of geometry on the fatigue crack growth rate. A series of fatigue tests on three-point bending specimens with different initial crack lengths were conducted.
Jaroslaw Galkiewicz +2 more
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Corrosion Fatigue of Austenitic Stainless Steels for Nuclear Power Engineering
Metals, 2016 Significant structural steels for nuclear power engineering are chromium-nickel austenitic stainless steels. The presented paper evaluates the kinetics of the fatigue crack growth of AISI 304L and AISI 316L stainless steels in air and in corrosive ...
Irena Vlčková +4 more
doaj +1 more source
Fatigue Crack Growth Rate Description of RF-Plasma-Sprayed Refractory Metals and Alloys. [PDF]
Materials (Basel), 2023 Kovarik O, Cizek J, Klecka J.
europepmc +1 more source
Simulation of Crack Growth Rate in Martensitic Steel
Journal of Applied Sciences, 2007 This research used the stress intensity factor with rate of crack growth per cycle to model and simulate the crack growth in martensitic steel in air environment. The basic parameter used were da/dN and ΔK, log (da/dN) was analyzed against log ΔK and a regression analysis using data from log (da/dN) vs log (ΔK) was carried out and the outcome employed ...
Odukwe, O. A. +2 more
openaire +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2014 The stress intensity factor can be applied as an evaluation parameter of crack growth under small-scale yielding conditions. Moreover, the stress intensity factor corrected by the plastic zone correction can potentially be used as an evaluation parameter
Sho KAWATSU +4 more
doaj +1 more source