Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
EXPERIMENT STUDY ON CRACK GROWTH RATE OF ADB610 STEEL UNDER DIFFERENT STRESS RATIOS
Jixie qiangdu, 2016 The test of the fatigue crack growth rate under five stress ratios（ R = 0. 1,0. 2,0. 3,0. 4 and 0. 5） is completed used the compact tensile specimen. The test data are processed by using incremental polynomial method and the expressions and curves of ...
WEI Long +3 more
doaj
Investigation of the Combined Influence of Temperature and Humidity on Fatigue Crack Growth Rate in Al6082 Alloy in a Coastal Environment. [PDF]
Materials (Basel), 2023 Alqahtani I, Starr A, Khan M.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Constraint effect on corrosion fatigue crack growth behavior of A100 ultrahigh strength steel
Journal of Aeronautical MaterialsUltrahigh strength steel has been widely used to manufacture aircraft landing gear and other load-bearing structures，which is prone to corrosion fatigue failure when serving in harsh marine environment.
LI Yizhe +4 more
doaj +1 more source
Fatigue Crack Growth Rate Description of RF-Plasma-Sprayed Refractory Metals and Alloys. [PDF]
Materials (Basel), 2023 Kovarik O, Cizek J, Klecka J.
europepmc +1 more source
The Influence of In-Plane Constraints on Fatigue Crack Growth Rate
Advances in Science and Technology Research JournalThe geometry of structural members can influence the fatigue crack growth rate. In the paper, the T-stress depending on the element's geometry is used to quantify the effect of geometry on the fatigue crack growth rate. A series of fatigue tests on three-point bending specimens with different initial crack lengths were conducted.
Jaroslaw Galkiewicz +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Study on the influence of shot peening strengthening before shot peen forming on 2024-T351 aluminum alloy fatigue crack growth rate. [PDF]
Sci Rep, 2023 Li G, Dong Z, Luo T, Huang H.
europepmc +1 more source