Results 51 to 60 of about 25,127 (264)

EXPERIMENTAL STUDY ON CRACK GROWTH RATE OF B780CF STEEL WELDED JOINTS UNDER DIFFERENT WELDING PROCESS

Jixie qiangdu, 2018
The fatigue crack growth rate under different welding process was tested with standard compact tension specimen,the test data are processed by using incremental polynomial method and the crack growth rate curve under different welding process was ...
SHENG ShouYong, WANG ShiYue, LIU GuoShou, ZHENG YiHua   +3 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

In-situ SEM and optical microscopy testing for investigation of fatigue crack growth mechanism under overload

MATEC Web of Conferences, 2018
In this paper, the in-situ scanning electron microscope (SEM) and optical microscopy experiments are performed to investigate the crack growth behavior under the single tensile overload. The objectives are to (i) examine the overload-induced crack growth
Zhang Wei, Cai Liang
doaj   +1 more source

Corrosion Fatigue of Austenitic Stainless Steels for Nuclear Power Engineering

Metals, 2016
Significant structural steels for nuclear power engineering are chromium-nickel austenitic stainless steels. The presented paper evaluates the kinetics of the fatigue crack growth of AISI 304L and AISI 316L stainless steels in air and in corrosive ...
Irena Vlčková, Petr Jonšta, Zdeněk Jonšta, Petra Váňová, Taťána Kulová   +4 more
doaj   +1 more source

A Unified Equation for Predicting Crack Growth in Rubber Composites Across All Crack Growth Rates

Polymers
The relationship between tearing energy and crack growth rates in elastomers is typically divided into three regions—slow crack growth, fast crack growth, and a transitional region—each described by separate power law relationships, requiring six variables to fully characterize the behavior.
Aaron M. Duncan, Keizo Akutagawa, Dimitrios G. Papageorgiou, Julien L. Ramier, James J. C. Busfield   +4 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Small fatigue crack growth behavior of TB6 titanium alloy

Cailiao gongcheng, 2019
The growth behavior of naturally-initiated small cracks in single edge notched tensile (SENT) specimen of TB6 titanium alloy was studied. Fatigue experiments were conducted under constant amplitude loading with the stress ratios R of 0.1 and 0.5 at room ...
XU Liang, HUANG Shuang-jun, HUI Li, WANG Lei, ZHOU Song, ZHAO Qing   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of Notches on Fatigue Crack Initiation and Early Propagation Behaviors of a Ni-Based Superalloy at Elevated Temperatures

Metals
The role of notch stress and surface defects on fatigue crack initiation and small-crack propagation behavior has been investigated using groove simulation specimens.
Zuopeng Zhao, Xuteng Hu, Zhiwei Guo
doaj   +1 more source