Results 111 to 120 of about 231,658 (310)

Low Temperature Fatigue Crack Growth Test and Life Estimation of 7475-T7351 Al-ally by ANN [PDF]

, 2016
In the present wok fatigue crack growth tests have been performed under interspersed mode-I overload on 7475-T7351 Al-alloy. The overloads with an overload ratio of 2 were given at 0C, ndash;30C, ndash;45C, ndash;60C, and ndash;75C at a loading rate of 7
Mohanty, J. R. (J)
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The Influence of In-Plane Constraints on Fatigue Crack Growth Rate

Advances in Science and Technology Research Journal
The geometry of structural members can influence the fatigue crack growth rate. In the paper, the T-stress depending on the element's geometry is used to quantify the effect of geometry on the fatigue crack growth rate. A series of fatigue tests on three-point bending specimens with different initial crack lengths were conducted.
Jaroslaw Galkiewicz, Urszula Janus-Galkiewicz, Sebastian Lipiec   +2 more
openaire   +1 more source

Flaw growth behavior in thick welded plates of 2219-T87 aluminum at room and cryogenic temperatures [PDF]

Axial load fatigue and fracture tests were conducted on thick welded plates of 2219-T87 aluminum alloy to determine the tensile strength properties and the flaw growth behavior in electron beam, gas metal arc, and pulse current gas tungsten arc welds for
Forman, R. G., Glorioso, S. V., Medlock, J. D.   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Constraint Aspects of the Evaluation of Fatigue Test Results in Paris Region

Communications, 2006
The growth of the fatigue crack is dependent on the crack growth resistance of the material as a bulk property. The fatigue crack growth properties of a material are usually described by the correlation between a crack propagation rate, and a ...
Zdenek Knesl, Pavel Hutar, Stanislav Seitl   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

RESEARCH ON FATIGUE CRACK PROPAGATION OF LEAF SPRING UNDER VARIABLE AMPLITUDE LOAD

Jixie qiangdu, 2021
The prediction model of leaf springs fatigue crack growth under variable amplitude loads is mainly Schütz phenomenological model. However, the effect of the crack closure effect on fatigue crack propagation and the relationship between the parameters and
XIANG YuXia, WU ZhiFei
doaj  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Characterization of crack growth under combined loading [PDF]

Room-temperature static and cyclic tests were made on 21 aluminum plates in the shape of a 91.4x91.4-cm Maltese cross with 45 deg flaws to develop crack growth and fracture toughness data under mixed-mode conditions.
Feldman, A., Holston, A., Jr., Smith, F. W.   +2 more
core   +1 more source