Results 121 to 130 of about 42,379 (316)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2016 For high-strength steels, the crack initiation of very-high-cycle fatigue (VHCF) is commonly at the interior of material with fish-eye (FiE) morphology containing a fine-granular-area (FGA) surrounding an inclusion as crack origin, and FGA is regarded ...
孙成奇 +8 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
High-cycle Rotate Bending Fatigue Behavior of TC17 at Elevated Temperature
工程科学与技术, 2014 :Rotating bending (50 Hz)fatigue tests were performed at room temperature,200 ℃ and 350 ℃,respectively,to evaluate the influence of temperature on the fatigue resistance and fatigue crack growth rates of TC17 alloy.Variation of sample deflection was used
李久楷, 刘永杰, 王清远, 侯方
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Micromechanistic analysis of fatigue in aluminium silicon casting alloys
, 2007 Due to increasingly stringent environmental legislation, there is a requirement for lower emissions and greater overall efficiency of light vehicle diesel (LVD) engines.
Moffat, Andrew James
core
Experimental Studies on the Crack Initiation and Propagation of Hydraulic Fracturing with Different Coal Structure Combinations. [PDF]
ACS Omega, 2023 Liu D +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
ANALYSIS OF THE CONSTRAINT EFFECT AND CREEP CRACK INITIATION TIME FOR STRUCTURE WITH ЕMBEDDED CRACKS
Jixie qiangduThe specimen structure with embedded cracks served at elevated temperature was studied. The constraint effect and creep crack initiation time were analysed using the ductility exhaustion approach by 3D finite element method. The results revealed that the
LI YuPeng +5 more
doaj
Materials & DesignFracture toughness JIC (the critical J-integral at crack initiation) is a crucial indicator for characterizing the crack resistance of materials. For high density polyethylene (HDPE), the multi-specimen method is generally adopted to construct crack ...
Yue Zhang +3 more
doaj +1 more source