Results 111 to 120 of about 652,868 (246)
MATEC Web of Conferences, 2018 Cyclic torsional fatigue properties of a high strength steel 100Cr6 are investigated using an ultrasonic torsional fatigue testing machine, and the results are compared with those obtained with fatigue tests under axial loading.
Xue Hongqian +3 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
High-cycle Rotate Bending Fatigue Behavior of TC17 at Elevated Temperature
工程科学与技术, 2014 :Rotating bending (50 Hz)fatigue tests were performed at room temperature,200 ℃ and 350 ℃,respectively,to evaluate the influence of temperature on the fatigue resistance and fatigue crack growth rates of TC17 alloy.Variation of sample deflection was used
李久楷, 刘永杰, 王清远, 侯方
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Experimental and theoretical studies of corrosion fatigue in a high strength steel. [PDF]
, 1995 The present work consists of both experimental and theoretical aspects of corrosion fatigue in a high strength steel. Fatigue tests were conducted under fully reversed shear loading in an aerated 0.6M NaC1 solution at pH6, for a silico-manganese ...
Wu, Xiao Dong
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ANALYSIS OF THE CONSTRAINT EFFECT AND CREEP CRACK INITIATION TIME FOR STRUCTURE WITH ЕMBEDDED CRACKS
Jixie qiangduThe specimen structure with embedded cracks served at elevated temperature was studied. The constraint effect and creep crack initiation time were analysed using the ductility exhaustion approach by 3D finite element method. The results revealed that the
LI YuPeng +5 more
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