Results 111 to 120 of about 42,379 (316)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
MATEC Web of Conferences, 2018 Cyclic torsional fatigue properties of a high strength steel 100Cr6 are investigated using an ultrasonic torsional fatigue testing machine, and the results are compared with those obtained with fatigue tests under axial loading.
Xue Hongqian +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Experimental and theoretical studies of corrosion fatigue in a high strength steel. [PDF]
, 1995 The present work consists of both experimental and theoretical aspects of corrosion fatigue in a high strength steel. Fatigue tests were conducted under fully reversed shear loading in an aerated 0.6M NaC1 solution at pH6, for a silico-manganese ...
Wu, Xiao Dong
core
Journal of Materials Research and TechnologyThis study performed high-cycle fatigue tests on 316LN stainless steel (SS) for nuclear power application to evaluate its fatigue behavior at both room temperature (RT) and 350 °C.
JianNeng Zheng +4 more
doaj +1 more source
FEM Simulations of Fatigue Crack Initiation in the Oligocrystalline Microstructure of Stents. [PDF]
Materials (Basel), 2023 Lasko G +4 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 2010 Stress corrosion, SC, in some cases gives rise to stress corrosion cracking, SCC, which differs from purely stress intensity driven cracks in many aspects.
Hejman, Ulf
core
Fatigue strength and crack initiation mechanism of very-high-cycle fatigue for low alloy steels
, 2012 The fatigue strength and crack initiation mechanisms of very-high-cycle fatigue (VHCF) for two low alloy steels were investigated. Rotary bending tests at 52.5 Hz with hour-glass type specimens were carried out to obtain the fatigue propensity of the ...
赵爱国 +8 more
core +1 more source