Results 91 to 100 of about 42,379 (316)

Faceted crack initiation characteristics for high-cycle and very-high-cycle fatigue of a titanium alloy under different stress ratios

open access: yes, 2016
Ultrasonic fatigue tests were conducted at the stress ratios of -1, -0.5, -0.1, 0.1 and 0.5 for a Ti-6Al-4V alloy in high-cycle and very-high-cycle fatigue regimes. Experimental results showed that faceted crack initiation was the main failure mode for
孙成奇   +6 more
core   +1 more source

The Initiation Characteristics of Corrosion Fatigue Crack in 18Ni (250) Steel

open access: yesJournal of Marine Science and Engineering
Maraging steel is the material of deep sea pressure equipment. The characteristics of corrosion fatigue crack initiation in 18Ni (250) were investigated by performing a tensile fatigue test under different loading conditions.
Hongzhang Pan   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

WEAR AND CRACK initiation PREDICTION OF RAIL IRREGULARITY WELDING ZONE

open access: yesJixie qiangdu
In order to investigate the relationship between abrasion and crack initiation in the welded zone of rails and axle weight and friction coefficient, through the field measurement of a large number of uneven weld zones, two kinds of typical weld zone ...
WEAR AND   +1 more
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

An energy-equilibrium model for complex stress effect on fatigue crack initiation

open access: yes, 2014
Based on Tanaka and Mura's fatigue model and Griffith theory for fracture, an energy-equilibrium model was proposed to explain the complex stress effect on fatigue behavior.
Xie, JJ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.   +4 more
core   +1 more source

Fatigue Crack Initiation and Small Crack Propagation Behaviors of Simulated Specimens in a Ni-Based Superalloy

open access: yesMetals
The role of notch geometry and stress levels on fatigue crack initiation and small crack propagation behavior in the FGH96 superalloy was investigated using groove and bolt hole simulated specimens at 500 °C.
Zuopeng Zhao, Xuteng Hu, Zhiwei Guo
doaj   +1 more source

In Situ Fatigue Crack Analysis of 590 Wheel Steel in Different States

open access: yes工程科学与技术, 2023
Fatigue crack is the main failure course of wheel steels, but its relationship with microstructure, texture, welding process and deformation remains unclear.
Ning CAI   +5 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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