Results 71 to 80 of about 652,868 (246)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Cracking Mode Analysis of Crack Initiation in Rocks under Uniaxial Compression
Advances in Civil Engineering, 2019 Crack initiation is related to the behavior of the preexisting microcracks within a rock specimen, which suggests the specimen starts to fail. The determination of crack initiation stress is important for identifying the elastic stage and related ...
Ye Lou, Guangqing Zhang, Xiaoxiao Wang
doaj +1 more source
Onset of Crack Initiation in Uniaxial and Triaxial Compression Tests of Dolomite Samples
Studia Geotechnica et Mechanica, 2014 The paper presents results of laboratory investigation and analysis of crack initiation threshold identification of dolomite samples. First, selected methods for determining crack initiation thresholds are briefly described with special attention paid to
Cieślik Jerzy
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Framework for Predicting Fatigue Crack Initiation Life in Pipelines with Girth Welds
Journal of Marine Science and EngineeringCurrent studies on fatigue crack initiation in pipelines remain relatively limited. Existing frameworks are confronted with issues including difficulties in crack monitoring and limited consideration of intragranular short-crack propagation.
Jianxing Yu +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Crack initiation stress and crack initiation strain in each model.
, 2022 Crack initiation stress and crack initiation strain in each model.
Jialiang Wang (115197) +6 more
core +1 more source
Nihon Kikai Gakkai ronbunshu, 2014 Initiation and growth behaviors of a transverse crack occurred in interlaminar toughened CFRP cross-ply laminates under cyclic loading were evaluated. Specimens whose stacking sequence is [0/904]S and [0/906]S were formed with T800S/3900-2B prepreg.
Hiroyuki KAWADA +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source