Results 61 to 70 of about 652,868 (246)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

EXPERIMENT AND SIMULATION RESEARCH ON UNIFORM SUPERCHARGED FATIGUE CRACK INITIATION OF AIRCRAFT FUSELAGE SKIN

Jixie qiangdu, 2020
The fatigue crack initiation of the fuselage structure skin under the uniform supercharged cyclic load of 0 ～ 7. 8 Psi was experimentally studied by the self-made aircraft fuselage skin uniform supercharged fatigue simulation device.
LIU LiPing, ZHANG Fang, ZHONG XiaoKun, BAO Rui, XU JianXin, QIN WenChao   +5 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Crack initiation and propagation at crack tips of prefabricated flawed sandstone under uniaxial compression

Scientific Reports
In order to explore the crack initiation and propagation law of fractured rock, uniaxial compression test and DIC digital speckle test were carried out on prefabricated crack specimens with different dip angles, and high-definition camera was used to ...
Cheng Jiang, Xingxing Zhang, Yi Wang, Qiaohui Hei, Hangye Ma, Hongyuan Huai   +5 more
doaj   +1 more source

Crack initiation characteristics of brittle rock under coupled hydraulic pressure and triaxial static-dynamic loading

Journal of Rock Mechanics and Geotechnical Engineering
In this study, a modified hydraulic pressure loading apparatus was designed to apply hydraulic pressure to crack surface and to measure crack initiation stress (σi).
Shaobo Jin, Wentao Yang, Qiuhua Rao, Wei Yi, Pingyang Wu   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Fatigue crack initiation and growth in a 35CrMo4 steel investigated by infrared thermography [PDF]

, 2005
The present work is devoted to the investigation of fatigue crack initiation and growth in middle-cycle fatigue (∼105 cycles). Smooth specimens made of 35CrMo4 quenched and tempered steel were loaded in fully reversed plane bending.
UVAROV, S., PALIN-LUC, Thierry, NAIMARK, O.B, NAIMARK, O.B., PALIN LUC, Thierry, SAINTIER, Nicolas, UVAROV, S. V., PLEKHOV, O.A, PLEKHOV, O.   +8 more
core   +1 more source

Crack path in aeronautical titanium alloy under ultrasonic torsion loading

Fracture and Structural Integrity, 2015
This paper discusses features of fatigue crack initiation and growth in aeronautical VT3-1 titanium alloy under pure torsion loading in gigacycle regime. Two materials: extruded and forged VT3-1 titanium alloys were studied.
A. Nikitin, C. Bathias, T. Palin-Luc, A. Shanyavskiy   +3 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Simulation Study on the Influence of Reactions Between Granitic Hot Dry Rock Minerals and Water on Rock Non-Closed Crack Compressive Shear Initiation

Applied Sciences
The development of hot dry rock needs working fluids, and mineral reactions happen due to contact between hot dry rock minerals and fluids. Mineral reactions influence hot dry rock reservoir characteristics, whereas their impacts on hot dry rock ...
Ou Jiang, Xiuhua Zheng, Hongyan Liu, Wenxi Zhu, Haidong Wu   +4 more
doaj   +1 more source