Results 31 to 40 of about 27,989 (216)
Applied SciencesThe parallel steel wires used in arch bridge suspenders experience random corrosion damage on their surfaces during service. Corrosion damage, including micro-cracks, pitting, and a combination of both, leads to significant stress concentration under ...
Luming Deng, Yulin Deng
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Evaluation of Fatigue Crack Growh Resistance of Rubber-Silica Composites and Analysis of the Role of Filler-Filler Interaction and Interface Bonding [PDF]
علوم و تکنولوژی پلیمر, 2019 Hypothesis: Fatigue crack growth (FCG) of rubber composites as controlled by the viscoelastic losses, is strongly dependent on the polymer-filler interfacial phenomena.
Mohammad Alimardani +1 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Applied SciencesFor the purpose of Fitness-For-Service analysis, the effect of a semi-elliptical surface crack on a parallel quarter-circle corner crack in a semi-infinite solid subjected to pure bending is studied using 3D finite element analyses.
Mordechai Perl, Qin Ma, Cesar Levy
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Fracture of Brazilian Disc with Double 60° Internal Cracks Based on 3D-ILC
工程科学与技术, 2020 The interaction between cracks is an important research content of fracture mechanics. However, there are few studies on the internal cracks interactions. Based on 3D-ILC, parallel internal cracks in the brittle solids have been generated.
Haijun WANG +4 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source