Results 51 to 60 of about 222,942 (303)

Creep and Fracture in Concrete: A Fractional Order Rate Approach [PDF]

, 2002
The paper analyses the interaction between strain-softening and time-dependent behaviour in the case of quasi-static fracture of concrete. A viscous element based on a fractional order rate law is coupled with a micromecanical model for the fracture ...
Barenblatt, Barpi, Barpi, Bažant, Bocca, Carpinteri, Carpinteri, Carpinteri, Dugdale, Enelund, F. Barpi, Hillerborg, Huang, Karihaloo, Oldham, S. Valente, Santhikumar, Santhikumar   +17 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Investigation of the Damage Mechanisms Influencing the Short Crack Behavior of Inconel 625 Under Variable Amplitude Fatigue Loading

Aerospace
Variable amplitude fatigue loading can result in both accelerated and decelerated fatigue damage due to load interaction effects. Short fatigue cracks in particular exhibit a wide range of crack growth behavior due to multiple damage mechanisms ...
Robert Fleishel, Reza Abedi, Stephanie TerMaath   +2 more
doaj   +1 more source

Interactions of double slanted cracks under mode I loading

MATEC Web of Conferences, 2017
This paper presents numerical analysis of double slanted central cracks in square plates under mode I tension stress. ANSYS finite element program is used to model and solve the problem of slanted cracks where the stress intensity factor is determined ...
Ismail Al Emran, Zainulabidin Muhd Hafeez, Noor Fazimah Mat, Wahab Hanani Abd, Ismon Maznan, Mohamad Zaleha, Madlan Mohd Amran   +6 more
doaj   +1 more source

A numerical study on impact and compression after impact behaviour of variable angle tow laminates [PDF]

, 2013
Recent developments of variable angled tow (VAT) technology have indicated that variable stiffness composite laminates offer a strong potential for structural tailoring.
Dang, Thi D., Hallett, Stephen R.
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Observation and analysis of process zone–crack interaction in crack layer during fatigue crack propagation in polypropylene

Journal of Materials Research and Technology
Fatigue crack propagation in polypropylene, despite its significance in a wide range of structural applications, has not been sufficiently researched because of the complex interaction between the crack tip and process zone ahead of the crack tip.
Sang Min Lee, Ilhyun Kim, Byoung-Ho Choi
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source