Results 71 to 80 of about 222,942 (303)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Insights into the X-shaped fissure propagation and interaction mechanisms of rock specimens: 3D printing experiments and DEM simulations

Case Studies in Construction Materials
X-shaped fissures are prevalent in natural rocks and significantly influence rock mass stability, yet their interaction and propagation mechanisms remain inadequately studied.
Yiqing Sun, Wei Huang, Lei Gan, Zhenzhong Shen, Hongwei Zhang, Wenbing Zhang   +5 more
doaj   +1 more source

Stress intensity factors computation for bending plates with extended finite element method [PDF]

, 2012
The modelization of bending plates with through-the-thickness cracks is investigated. We consider the Kirchhoff–Love plate model, which is valid for very thin plates.
Adams, Areias, Areias, Areias, Areias, Bordas, Béchet, Ciarlet, Ciarlet, Ciarlet, Destuynder, Destuynder, Dolbow, Grisvard, Hui, Laborde, Lasry, Liu, Moës, Moës, Moës, Nicaise, Song, Sukumar, Viz, Wyart, Zehnder, Zi, Zucchini   +28 more
core   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combustion: Structural interaction in a viscoelastic material [PDF]

The effect of interaction between combustion processes and structural deformation of solid propellant was considered. The combustion analysis was performed on the basis of deformed crack geometry, which was determined from the structural analysis. On the
Chang, J. P., Chang, T. Y., Kumar, M., Kuo, K. K.   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interaction between line cracks in an orthotropic layer

International Journal of Mathematics and Mathematical Sciences, 2002
We deal with the interaction between three coplanar Griffith cracks located symmetrically in the mid plane of an orthotropic layer of finite thickness 2h. The Fourier transform technique is used to reduce the elastostatic problem to the solution of a set
Subir Das
doaj   +1 more source

Fatigue crack growth. Overload and underload interactions [PDF]

, 2006
This article deals with the study of the overload- underload interactions effects on fatigue crack growth (FCG) rate. With the purpose of understanding of overload-underload interaction mechanisms the FEM modeling of stress-strain state at the crack tip ...
Fostyk, V., Pyndus, Yu., Shulgan, I., Yasniy, P.   +3 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source