Results 81 to 90 of about 28,118 (298)

Interaction between line cracks in an orthotropic layer

International Journal of Mathematics and Mathematical Sciences, 2002
We deal with the interaction between three coplanar Griffith cracks located symmetrically in the mid plane of an orthotropic layer of finite thickness 2h. The Fourier transform technique is used to reduce the elastostatic problem to the solution of a set
Subir Das
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Vector J-integral analysis of crack interaction with pre-existing singularities

, 2006
In this paper, the mechanics of a semi-infinite crack interacting with near crack-tip singularities (e.g., dislocations) in two-dimensional solids is investigated using the concept of potential energy release rate.
Korsunsky, Alexander, Lu, TJ, Ma, L
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A study of multiple crack interaction at rolling contact fatigue loading of rails

, 2009
The objective of this paper is to investigate geometric and material parameters that affect the interaction of multiple pre-existing (initiated) cracks due to rolling contact fatigue (RCF) loading conditions. In particular, the behaviour of short cracks (
Larsson, Fredrik, Tillberg, Johan, Larsson, Fredrik,, Runesson, Kenneth, Tillberg, Johan,, Runesson, Kenneth,   +5 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Elastic crack interaction limit of two interacting edge cracks in finite body

, 2012
International Conference on Applications and Design in Mechanical Engineering 2012 (ICADME 2012) organized by School of Mechatronic Engineering, Universiti Malaysia Perlis (UniMAP), 27th - 28th Februari 2012 at Bayview Beach Resort, Penang, Malaysia.In ...
A. K., Ariffin, M. A., Rojan, R., Daud, S., Abdullah   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Study on crack interaction effect of API steel using finite element analysis [PDF]

, 2012
This project is a study on crack interaction effect of API steel using Finite Element Analysis (FEA). The objectives for this project are to study the interaction of two noncoplanar cracks and analyze the maximum stress for various crack size and ...
Ahmad Syauqi Fathuddin, Md Shaimi
core  

On the Energy Release Rate of a Crack with a Parallel Interacting Crack.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1998
In this paper, we investigate crack extension behaviors for a linear elastic body with a parallel interacting crack at the neighborhood of the main crack tip. We compute the energy release rate for all the crack tips at the onset of a main crack kinking : E integral is path independent even for a path containing a kinking crack tip and/or the ...
ABE, Takahiro, HASHIMOTO, Kenichi, YATOMI, Chikayoshi   +2 more
openaire   +2 more sources