Results 101 to 110 of about 28,118 (298)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Interaction of surface and internal cracks in railhead

Computer Assisted Methods in Engineering and Science, 2022
This paper presents a two-dimensional model for the analysis of interaction between surface and internal cracks in the railheads subjected to wheel loading.
Manicka Dhanasekar, Jian-Jun Han, Qing Hua Qin   +2 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Strong embedded discontinuities for simulating fracture in quasi-brittle materials

, 2011
In this paper embedded strong discontinuities are used to model discrete cracking in materials like concrete. In the approach followed a discontinuous displacement field is considered and the deformation is localized at a surface of zero width.

core   +1 more source

Mechanism of crack branching in the fatigue crack growth path of 2324-T39 Aluminium alloy

Fracture and Structural Integrity, 2015
The crack growth behavior in 2324-T39 aluminium alloy was experimentally investigated. Two types of crack branching were observed. The mechanism of an uncommon crack branching which results from the link up of secondary crack with the main crack was ...
Lu Songsong, Bao Rui, Zhang Ting, Fei Binjun   +3 more
doaj  

Nonlinear Shear Waves for Structural Damage Detection – Crack-Wave Interaction Modelling and Numerical Simulations

e-Journal of Nondestructive Testing
The paper investigates ultrasonic nonlinear shear horizontal waves. The major focus of the work undertaken is on the fundamental mode due to its non-dispersive nature. Nonlinear crack-wave interaction is investigated.
Jakub Nowak, Rafał Radecki, Wieslaw Jerzy Staszewski   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Numerical Simulation of Crack Propagation in Dissimilar Metal Welded Region Based on Interaction Integral

Yuanzineng kexue jishu
A large number of dissimilar metal welded materials exist in nuclear power structures, so the accurate evaluation of crack propagation in welded region is highly relevant to the safe service of nuclear power equipment.
BAI Xiaoming1,  XIONG Furui1,  XIE Hai1,  SHI Kaikai1,  YU Xinyang1,  YU Hongjun2
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source