Results 101 to 110 of about 222,942 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A penny shaped crack in a filament-reinforced matrix. 2: The crack problem [PDF]
The elastostatic interaction problem between a penny-shaped crack and a slender inclusion or filament in an elastic matrix was formulated. For a single filament as well as multiple identical filaments located symmetrically around the crack the problem is
Erdogan, F., Pacella, A. H.
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Interaction of surface and internal cracks in railhead
Computer Assisted Methods in Engineering and Science, 2022 This paper presents a two-dimensional model for the analysis of interaction between surface and internal cracks in the railheads subjected to wheel loading.
Manicka Dhanasekar +2 more
doaj
Fatigue crack growth in a unidirectional SCS-6/Ti-15-3 composite [PDF]
An investigation was conducted to characterize and model the fatigue crack growth (FCG) behavior of a SCS-6/Ti-15-3 metal matrix composite. Part of the study was conducted using a fatigue loading stage mounted inside a scanning electron microscope (SEM).
Ghosn, Louis +2 more
core +1 more source
On the Energy Release Rate of a Crack with a Parallel Interacting Crack.
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1998 In this paper, we investigate crack extension behaviors for a linear elastic body with a parallel interacting crack at the neighborhood of the main crack tip. We compute the energy release rate for all the crack tips at the onset of a main crack kinking : E integral is path independent even for a path containing a kinking crack tip and/or the ...
Takahiro ABE +2 more
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
e-Journal of Nondestructive TestingThe paper investigates ultrasonic nonlinear shear horizontal waves. The major focus of the work undertaken is on the fundamental mode due to its non-dispersive nature. Nonlinear crack-wave interaction is investigated.
Jakub Nowak +2 more
doaj +1 more source
Review of the Effects of Microstructure on Fatigue in Aluminum Alloys [PDF]
Literature survey was conducted to determine the effects of different microstructural features and different load histories on fatigue crack initiation and propagation of aluminum alloys.
Telesman, J.
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source