Results 41 to 50 of about 222,942 (303)

Crack growth based life prediction approach under LCF-HCF interaction

Fracture and Structural Integrity, 2019
Prediction of cyclic life under low cycle fatigue - high cycle fatigue (LCF-HCF) interaction is of paramount importance in the context of structural integrity of components in the primary side of fast reactors where such damage under LCF-HCF interaction ...
A. Sarkar, A. Nagesha, R. Sandhya, M. Okazaki   +3 more
doaj   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Experimental study on interaction characteristics of explosive cracks under confining pressure and its comparison with free boundary results

Journal of Materials Research and Technology
The influence of confining pressure on the dynamic fracture mechanical behavior of deep rock masses is crucial in the exploitation of deep resources and the development of underground spaces.
Linzhi Peng, Zhongwen Yue, Xu Wang, Jun zhou   +3 more
doaj   +1 more source

Fatigue crack growth in a particulate TiB2 reinforced powder metallurgy iron-based composite

, 2003
Fatigue crack growth behavior has been examined in a particulate titanium diboride (TiB2)–reinforced iron-based composite that had been produced via a mechanical alloying process.
Sinclair, I., Yang, N.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Lifetime evaluation of concrete structures under sustained post-peak loading [PDF]

, 2005
Experimental tests on crack propagation in concrete under constant post-peak loading are simulated using the finite element method and the cohesive crack model, in both Mode I and Mixed-mode conditions.
Barpi, Fabrizio, Valente, Silvio
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Interaction between offset parallel cracks in rock

Yantu gongcheng xuebao, 2017
The interaction of cracks with different locations and sizes is a key factor leading to the damage of rock. Based on the Kachanov method, the interaction rules between two offset parallel cracks with different level intervals, vertical intervals, crack ...
ZHU Di-jie 1, CHEN Zhong-hui 1, XI Jing-yi 2, YANG Deng-feng 1
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source