Results 31 to 40 of about 28,921 (264)
Dynamic Crack Initiation Toughness of Shale under Impact Loading
Energies, 2019 The impact loading of a notched semi-circular bend (NSCB) specimen of outcrop shale in Changning Sichuan was carried out using a split Hopkinson pressure bar (SHPB) to study the effect of shale bedding on the dynamic crack initiation toughness.
Guoliang Yang +3 more
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Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Mathematics, 2022 In order to determine the effect of internal cracks on the tensile failure of materials, a hybrid finite–discrete element method was used to analyze the Brazilian disc test with cracks of different angles.
Xiaoyan Luo +3 more
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2018 Fatigue crack propagation in a polycrystalline Ni-base superalloy was experimentally investigated at room temperature. Fatigue crack propagation tests were conducted under a constant ΔK condition to clarify the effect of grains crystal orientation, grain
Mana HIGAKI +6 more
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Crack tip solution for Mode III cracks in spring interfaces
Engineering Fracture Mechanics, 2023 Considering an infinite linear elastic isotropic solid in antiplane shear, the Mode III crack-tip solution for a semi-infinite crack located in a straight spring interface is systematically studied for the first time. A new analytic expression for this crack-tip solution is given in the form of a double asymptotic series of the main and the so-called ...
Sara Jiménez-Alfaro, Vladislav Mantič
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FREE VIBRATION ANALYSIS OF A SIMPLY SUPPORTED BEAM WITH A VERTICAL EMBEDDED CRACK
Jixie qiangdu, 2016 Local stiffness and performances of a beam structure will be changed by a crack,which causes changes in mode parameters. Focused on this problem,a simply supported beam is studied based on finite element method.
SONG XiaoHua, LIU Jing
doaj