Results 51 to 60 of about 30,437 (264)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

FREE VIBRATION ANALYSIS OF A SIMPLY SUPPORTED BEAM WITH A VERTICAL EMBEDDED CRACK

open access: yesJixie qiangdu, 2016
Local stiffness and performances of a beam structure will be changed by a crack,which causes changes in mode parameters. Focused on this problem,a simply supported beam is studied based on finite element method.
SONG XiaoHua, LIU Jing
doaj  

Mode shape curvature of multiple cracked beam and its use for crack identification in beam-like structures

open access: yesVietnam Journal of Mechanics, 2020
The problem of using the modal curvature for crack detection is discussed in this paper based on an exact expression of mode shape and its curvature.
Nguyen Tien Khiem
doaj   +1 more source

Numerical study of crack path by MMCG specimen using M integral [PDF]

open access: yesFracture and Structural Integrity, 2016
The mixed mode loading configuration occurs in many civil engineering and mechanical applications. In wood material, the study of this problem is very important due to the orthotropic character and the heterogeneity of the material.
S. El Kabir   +4 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

A unique fracture in fatigue of age-hardened Al alloys and its macro and microscopic aspects

open access: yesNihon Kikai Gakkai ronbunshu, 2017
There are many studies reported that a fatigue crack propagated in a tensile mode macroscopically and the fracture surface was mainly occupied by striations in many metals.
Norio KAWAGOISHI   +4 more
doaj   +1 more source

Fracture Process and Failure Mode of Brazilian Discs with Cracks of Different Angles: A Numerical Study

open access: yesMathematics, 2022
In order to determine the effect of internal cracks on the tensile failure of materials, a hybrid finite–discrete element method was used to analyze the Brazilian disc test with cracks of different angles.
Xiaoyan Luo   +3 more
doaj   +1 more source

FRACTURE CRITERIA FOR COMBINED MODE CRACKS

open access: yes, 1978
The complex variable method is employed to analyse the energy release rate for combined mode cracks. A functional integral equation, which contains no singularity, is derived for a branched crack problem by a functional transformation. The integrand φ_1'(z) is expanded in eigenfunctions. The energy fracture criterion for the combined mode (K_Ⅰ and K_Ⅱ)
openaire   +3 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

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