Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Nonlinear dynamics of a rotating shaft with a breathing crack [PDF]
, 2011 In this paper, the effects of a breathing crack on the vibratory characteris- tics of a rotating shaft are investigated. A new, simple and robust model composed of two rigid bars connected with a nonlinear flexural spring is proposed.
Saber El Arem +3 more
core +1 more source
MIXED-MODE CRACK GROWTH IN WOOD
Pro Ligno, 2012 In timber elements the mixed mode depends essentially of wood anatomy and load configuration.In these conditions, in order to evaluate the material behavior and the fracture process, it’s necessary to separate the part of each mode. The mixed mode separation allows evaluating the amplitude of fracture mode. In the present paper, using a mixedmode crack
Pop, Octavian +2 more
openaire +2 more sources
FREE VIBRATION ANALYSIS OF A SIMPLY SUPPORTED BEAM WITH A VERTICAL EMBEDDED CRACK
Jixie qiangdu, 2016 Local stiffness and performances of a beam structure will be changed by a crack,which causes changes in mode parameters. Focused on this problem,a simply supported beam is studied based on finite element method.
SONG XiaoHua, LIU Jing
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Fatigue crack growth in thin notched woven glass composites under tensile loading. Part II: modelling [PDF]
, 2011 Fatigue propagation of a through-the-thickness crack in thin woven glass laminates is difficult to model when using homogeneous material assumption. Crack growth depends on both the fatigue behaviour of the fibres and of the matrix, these two phenomena ...
Barrau, Jean-Jacques +7 more
core +1 more source
On Mode I crack mechanism in the puncturing of soft tissues
Procedia Structural Integrity, 2022 cutting, puncturing, soft material, sharpness, fracture ...
Spagnoli A. +5 more
openaire +3 more sources
A unique fracture in fatigue of age-hardened Al alloys and its macro and microscopic aspects
Nihon Kikai Gakkai ronbunshu, 2017 There are many studies reported that a fatigue crack propagated in a tensile mode macroscopically and the fracture surface was mainly occupied by striations in many metals.
Norio KAWAGOISHI +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Fatigue crack growth in thin notched woven glass composites under tensile loading. Part I: experimental [PDF]
, 2011 Helicopter blades are made of composite materials mainly loaded in fatigue and have normally relatively thin skins. A through-the-thickness crack could appear in these skins.
Barrau, Jean-Jacques +7 more
core +1 more source