Results 71 to 80 of about 4,438,483 (347)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Numerical study of crack path by MMCG specimen using M integral [PDF]
Fracture and Structural Integrity, 2016 The mixed mode loading configuration occurs in many civil engineering and mechanical applications. In wood material, the study of this problem is very important due to the orthotropic character and the heterogeneity of the material.
S. El Kabir +4 more
doaj +1 more source
Microstructural modelling of creep crack growth from a blunted crack [PDF]
, 1998 The effect of crack tip blunting on the initial stages of creep crack growth is investigated by means of a planar microstructural model in which grains are represented discretely. The actual linking-up process of discrete microcracks with the macroscopic
Giessen, E. van der,, Onck, P.R.,
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The post-yield fracture of a ductile polymer film: Notch quality, essential work of fracture, crack tip opening displacement, and J-integral [PDF]
, 2017 Double edge notched tension (DENT) specimens of a polyethylene terephthalate (PET) film were tested in an universal testing machine, measuring the displacements and the ligament lengths with a digital image correlation (DIC) system.
Arencón Osuna, David +3 more
core +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Fatigue. Mode III Fatigue Crack Growth Behavior. Transition Condition of the Crack Growth Mode.
Journal of the Society of Materials Science, Japan, 2001 Mode III fatigue crack is usually observed at the root of circumferentially notched round bar. As the crack grows in the depth direction of specimen, the growth rate of crack decreases. In this respect, crack mode transition from mode III to mode I is understood responsible. However, quantitative evaluation on crack mode transition has been hardly done.
Yukiyoshi KOBAYASHI +4 more
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source