Results 91 to 100 of about 4,438,483 (347)
Measurements of mixed-mode crack surface displacements and comparison with theory [PDF]
A theoretical and an experimental technique is used to determine crack surface displacements under mixed-mode conditions. Crack surface displacements proved to be quite useful in mode 1 fracture analysis in that they are directly related to strain energy
Altiero, N. J., Jr., Sharpe, W. N., Jr.
core +1 more source
Experimental Study on Mixed Mode Crack Propagation
Engineering Fracture Mechanics, 1989 Abstract The cracked specimens which are made of four kinds of brittle material have been tested under all possible combinations of modes I, II and III. On the basis of measured data, an empirical criterion of mixed mode crack propagation 0.05(K 1 /K Ic ) 2 + 0.95(K 1 /K Ic ) + 2.16(K 2 /K Ic ) 2 +
openaire +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Implementation of equivalent domain integral method in the two-dimensional analysis of mixed mode problems [PDF]
An equivalent domain integral (EDI) method for calculating J-intergrals for two-dimensional cracked elastic bodies is presented. The details of the method and its implementation are presented for isoparametric elements.
Raju, I. S., Shivakumar, K. N.
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Finite element analysis of fretting crack propagation
, 2011 In this work, the finite elements method (FEM) is used to analyse the growth of fretting cracks. FEM can be favourably used to extract the stress intensity factors in mixed mode, a typical situation for cracks growing in the vicinity of a fretting ...
Basseville, Stéphanie, Proudhon, Henry
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Peeling from a patterned thin elastic film
, 2004 Inspired by the observation that many naturally occurring adhesives arise as textured thin films, we consider the displacement controlled peeling of a flexible plate from an incision-patterned thin adhesive elastic layer.
Chaudhury, M. K. +4 more
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Crack path modelling in railway wheel under rolling contact fatigue
Applied and Computational Mechanics, 2015 A computational model of crack path for two-dimensional primary crack situated in a railway wheel rim is designed. The railway wheel rim is placed on the wheel disc of railway wheel with interference fit.
Kotoul M.
doaj