Results 111 to 120 of about 4,438,483 (347)
Micro-mechanical analysis of damage growth and fracture in discontinuous fiber reinforced metal matrix composites [PDF]
The near-crack-tip stresses in any planar coupon of arbitrary geometry subjected to mode 1 loading may be equated to those in an infinite center-cracked panel subjected to the appropriate equivalent remote biaxial stresses (ERBS).
Goree, James G., Richardson, David E.
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Experimental and analytical study of cracks under biaxial fatigue [PDF]
, 2016 Most mechanical components experience multi-axial cyclic loading conditions during service. Experimental analysis of fatigue cracks under such conditions is not easy and most works tend to focus more on the simpler but less realistic case of uni-axial ...
Camas, Daniel +5 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Composite interlaminar fracture toughness: Three-dimensional finite element modeling for mixed mode 1, 2 and 3 fracture [PDF]
A computational method/procedure is described which can be used to simulate individual and mixed mode interlaminar fracture progression in fiber composite laminates.
Chamis, C. C., Murthy, P. L. N.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Boundary force method for analyzing two-dimensional cracked bodies [PDF]
The Boundary Force Method (BFM) was formulated for the two-dimensional stress analysis of complex crack configurations. In this method, only the boundaries of the region of interest are modeled. The boundaries are divided into a finite number of straight-
Newman, J. C., Jr. +2 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Some exact results for the velocity of cracks propagating in non-linear elastic models
, 2006 We analyze a piece-wise linear elastic model for the propagation of a crack in a stripe geometry under mode III conditions, in the absence of dissipation.
E. A. Jagla +6 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source