Results 111 to 120 of about 2,476,755 (297)

Evolution of Crack Tip Constraint in a Mode II Elastic-Plastic Crack Problem

Physical Mesomechanics, 2018
Многочисленные исследования показали, что стесненная деформация в вершине трещины имеет существенное значение при изучении распространения трещины в рамках механики упругопластического разрушения. Влияние стесненности деформации подробно изучено в основном для задач чистого отрыва. Очень мало работ посвящено рассмотрению влияния стесненности деформации
Ayatollahi, MR, Berto, Filippo
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mode Stresses for the Interaction between an Inclined Crack and a Curved Crack in Plane Elasticity

Mathematical Problems in Engineering, 2015
The interaction between the inclined and curved cracks is studied. Using the complex variable function method, the formulation in hypersingular integral equations is obtained. The curved length coordinate method and suitable quadrature rule are used to solve the integral equations numerically for the unknown function, which are later used to evaluate ...
Nik Long, Nik Mohd Asri, Aridi, Mohd Radzi, Eshkuvatov, Zainidin K.   +2 more
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Analytical and Experimental Investigation of Rayleigh–Lamb Wave Interaction with a Surface-Breaking Crack

Acoustics
In this paper, a modal decomposition method is employed to analyze the properties of Rayleigh–Lamb waves propagating in an isotropic plate containing an open surface-breaking crack.
Peilong Yuan, Qiyuan Li, Xiaodong Shang, Anmin Yin, Xiaochuan Wang, Ming Guo, Kangning Jia, Qing Ji, Zhiqiang Zhang, Zhangsong Shi, Jiawei Zhang   +10 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Curve fitting of mixed-mode isopachics

, 2009
Recent work has focused on exploiting the observation that the stress-sum contours (isopachics), obtained from TSA, in the vicinity of the tip take the form of a simple curve – the cardioid.
Barton, Janice .M., Tatum, P., Worden, K., Hebb, R.I., Dulieu-Barton, J.M.   +4 more
core   +1 more source