Results 121 to 130 of about 4,438,483 (347)
ANALYSIS OF STRESS INTENSITY FACTOR AT THE CRACK TIP BASED ON THERMAL-MECHANICAL COUPLING
Jixie qiangduObjectiveTo clarify the failure mechanism and influencing factors of contact fatigue， improve the fatigue resistance of mechanical parts， and extend the fatigue life， research on the initiation and propagation mechanism of surface cracks under contact ...
ZHAO Zhongqiang +3 more
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
An equivalent domain integral method for three-dimensional mixed-mode fracture problems [PDF]
A general formulation of the equivalent domain integral (EDI) method for mixed mode fracture problems in cracked solids is presented. The method is discussed in the context of a 3-D finite element analysis.
Raju, I. S., Shivakumar, K. N.
core +1 more source
Steady-State Cracks in Viscoelastic Lattice Models II
, 1998 We present the analytic solution of the Mode III steady-state crack in a square lattice with piecewise linear springs and Kelvin viscosity. We show how the results simplify in the limit of large width. We relate our results to a model where the continuum
C. Bender +16 more
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Dynamic delamination crack propagation in a graphite/epoxy laminate [PDF]
Dynamic delamination crack propagation in a (90/0) 5s Graphite/Epoxy laminate with an embedded interfacial crack was investigated experimentally using high speed photography.
Grady, J. E., Sun, C. T.
core +1 more source
Perilaku Perambatan Retak Pada Aluminium Paduan A2024-T351 Dengan Menggunakan Spesimen CTS [PDF]
, 2007 Fracture behavior of aluminum alloys under mixed mode (Mode I+II) loading was studied. Fracture tests were carried out on A2024-T351 aluminum. Compact-tension-shear specimen was employed and angle between loading axis and the crack surface was varied ...
Husaini, H. (Husaini)
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Cracking Characteristics of Different Crack Forms in Pavement under Moving Load
Engineering TransactionsIn road engineering, the crack damage problems are one of the essential research areas that need to be emphasized. However, there have been few researches on the effects caused by different crack forms, e.g., the impacts of the distribution and ...
Guannan YAN
doaj +1 more source
Environmental fatigue of an Al-Li-Cu alloy. Part 3: Modeling of crack tip hydrogen damage [PDF]
Environmental fatigue crack propagation rates and microscopic damage modes in Al-Li-Cu alloy 2090 (Parts 1 and 2) are described by a crack tip process zone model based on hydrogen embrittlement. Da/dN sub ENV equates to discontinuous crack advance over a
Gangloff, Richard P., Piascik, Robert S.
core +1 more source