Results 101 to 110 of about 4,438,483 (347)
Scientific ReportsThe biaxial compression experiments of rock-like materials with two flaws are carried out under different flaw inclination angle, rock bridge ligament angle, lateral stress. The experimental studies show that crack propagation modes of rock-like material
Shuailong Lian +4 more
doaj +1 more source
The effects of crack surface friction and roughness on crack tip stress fields [PDF]
A model is presented which can be used to incorporate the effects of friction and tortuosity along crack surfaces through a constitutive law applied to the interface between opposing crack surfaces.
Ballarini, Roberto, Plesha, Michael E.
core +1 more source
, 2014 Drilling a hole at the crack tip turns the crack into a notch and diminishes the crack tip stress singularity. In this paper, the crack growth retardation is examined using a numerical study on the efficiency of stop holes.
M. Ayatollahi, S. Razavi, H. Chamani
semanticscholar +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Finite element analyses of fatigue crack growth under small scale yielding conditions modelled with a cyclic cohesive zone approach [PDF]
, 2013 Mode I fatigue crack growth is modelled and investigated with a cohesive zone approach. A 2D finite element boundary layer model under plane strain and small scale yielding conditions is used to generate fatigue crack growth rate curves ...
Kuna, Meinhard, Roth, Stephan
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Applied Sciences, 2018 The transverse crack in a non-uniform shaft possesses different crack modes, and it can affect the propagation characteristics of the elastic waves in the shaft.
Yimin Wei, Xuan Shi, Qi Liu, Wenhua Chen
doaj +1 more source