Results 41 to 50 of about 30,437 (264)

Non-invasive analysis of macro-crack on the characteristics of ultrasonic guided wave

Journal of Radiation Research and Applied Sciences, 2023
The effects of macro-crack in plates on the characteristic of ultrasonic guided wave were studied. Using the Finite Element Model and numerical calculation method, the finite element mesh models of various macro-crack in aluminum plate were established ...
Hanfei Zhang, Yanyan Luo
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

On the Path of a Quasi-static Crack in Mode III [PDF]

Journal of Elasticity, 2004
A method for finding the path of a quasi-static crack growing in a brittle body is presented. The propagation process is modelled by a sequence of discrete steps optimizing the elastic energy released. An explicit relationship between the optimal growing direction and the parameters defining the local elastic field around the tip is obtained for an ...
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dynamic Crack Initiation Toughness of Shale under Impact Loading

Energies, 2019
The impact loading of a notched semi-circular bend (NSCB) specimen of outcrop shale in Changning Sichuan was carried out using a split Hopkinson pressure bar (SHPB) to study the effect of shale bedding on the dynamic crack initiation toughness.
Guoliang Yang, Xuguang Li, Jingjiu Bi, Shuaijie Cheng   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Influences of crystal orientations and grain boundary on crack propagation behaviour at room temperature in a polycrystalline Ni-base superalloy

Nihon Kikai Gakkai ronbunshu, 2018
Fatigue crack propagation in a polycrystalline Ni-base superalloy was experimentally investigated at room temperature. Fatigue crack propagation tests were conducted under a constant ΔK condition to clarify the effect of grains crystal orientation, grain
Mana HIGAKI, Motoki SAKAGUCHI, Masafumi MATSUNAMI, Hideaki KANEKO, Takanori KARATO, Kenta SUZUKI, Hirotsugu INOUE   +6 more
doaj   +1 more source

Some Studies on Verifying the Applicability of Free Vibration-based Modes Shapes Method to Rectangular Shaped Cracks in a Cantilever Beam

U.Porto Journal of Engineering, 2022
Cracks weaken structures. When the crack size increases in service, the structure becomes weaker than its earlier condition. Lastly, the structure may break down due to a small crack.
vikas khalkar, S. G. Kumbhar, P. Hariharasakhtisudhan, A. A. M. Moshi, S. D. Jadhav, N. Kumbhar, P. Oak, P. S. Joshi   +7 more
doaj   +1 more source