Results 51 to 60 of about 21,684 (301)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Fatigue crack shielding in plain bearings under large scale yielding

, 2010
Multi-layered bearing systems used in the automotive industry show shielding and antishielding effects that reduce or amplify the crack driving force under large-scale yielding conditions. Using finite element analysis, it is shown that shielding in such
S. Syngellakis, P.A.S. Reed, Burke-Veliz, A., Reed, P.A.S., Syngellakis, S., A. Burke-Veliz   +5 more
core   +1 more source

Mechanics of the crack path formation [PDF]

International Journal of Fracture, 1991
A detailed analysis of experimentally obtained curvilinear crack path trajectories formed in a heterogeneous stress field is presented. Experimental crack path trajectories were used as data for numerical simulations, recreating the actual stress field governing the development of the crack path.
openaire   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Fracture Characteristics of 3D-Printed Polymer Parts: Role of Manufacturing Process

Journal of Manufacturing and Materials Processing
Using traditional methods to fabricate geometrically complicated items was challenging, but Additive Manufacturing (AM) has made it possible. Although AM (3D printing) was first developed to produce prototypes, in recent years it has also been utilized ...
Mohammad Reza Khosravani, Payam Soltani, Majid R. Ayatollahi, Tamara Reinicke   +3 more
doaj   +1 more source

Assessment of 3D Short Crack Closure in Ti-6Al-4V Alloy Utilizing Synchrotron X-ray Microtomography [PDF]

MATEC Web of Conferences, 2020
Synchrotron X-ray microtomography was utilized to observe the complex 3D crack morphology and the closure behavior of a short crack in Ti-6Al-4V alloy. The aim of the study was to investigate the effect of the crack path evolution on the 3D short crack ...
TUBEI Valary, HASSANIPOUR Meysam, HIRAYAMA Kyosuke, TODA Hiroyuki, TAKEUCHI Akihisa, UESUGI Kentaro   +5 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Constraints-related microscopic fatigue crack propagation behaviour of polycrystalline alloys

Heliyon
Based on the microscopic polycrystalline fatigue crack propagation (MPFCP) model, the MPFCP behaviours of GH4169 alloy under different micro-notch depths and lengths (constraints) were studied from aspects of MPFCP path, MPFCP rate and stress ...
Jie Yang, Hao-han Guo
doaj   +1 more source

Laser Powder Bed Fusion of Alumina: Effects of Scanning Strategies on External and Internal Defects

Advanced Engineering Materials, EarlyView.
This study investigates how scanning strategies affect pure alumina in laser powder bed fusion. Linear 45° scanning yields uniform surfaces but high porosity, while the island‐concentric strategy provides higher density with through‐holes favorable for infiltration. Findings highlight pathways toward optimizing defect‐free alumina parts.
Mohamed Abdelmoula, Gökhan Küçüktürk, Duran Kaya, David Grossin, Christophe Tenailleau, Benjamin Duployer, Enrique Juste, Fabrice Petit   +7 more
wiley   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source