Results 41 to 50 of about 26,362 (245)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Study of the Kalthoff–Winkler experiment using an ordinary state-based peridynamic model under low velocity impact

Advances in Mechanical Engineering, 2019
To overcome the limitation of constant Poisson’s ratio in bond-based peridynamics, an ordinary state-based peridynamic (OSB PD) model was applied to simulate dynamic crack propagation in Kalthoff–Winkler specimen subjected to a low velocity impact.
JS Guo, WC Gao
doaj   +1 more source

Edge crack growth of mortar plate specimens under uniaxial loading tests

Journal of Rock Mechanics and Geotechnical Engineering, 2019
In this paper, a compression-to-tension conversion technique is developed by applying predominant mode I loading test, using a servo-controlled compression system. The technique is applied to thin mortar plate specimens of different widths that include a
Zhenghong Huang, Shouchun Deng, Haibo Li, Hong Zuo   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analysis on the Root Crack Propagation Path and Its Influencing Factor of Spur Gear

Jixie chuandong, 2021
Under the action of alternating load，the gear is easy to generate fatigue crack fault in the tooth root，and the crack propagation will not only affect the transmission accuracy，but even cause serious safety accident and economic loss.
Qikun Liu, Shengli Wu, Zhi Li, Xiaochun Jian   +3 more
doaj  

Influences of crystal orientations and grain boundary on crack propagation behaviour at room temperature in a polycrystalline Ni-base superalloy

Nihon Kikai Gakkai ronbunshu, 2018
Fatigue crack propagation in a polycrystalline Ni-base superalloy was experimentally investigated at room temperature. Fatigue crack propagation tests were conducted under a constant ΔK condition to clarify the effect of grains crystal orientation, grain
Mana HIGAKI, Motoki SAKAGUCHI, Masafumi MATSUNAMI, Hideaki KANEKO, Takanori KARATO, Kenta SUZUKI, Hirotsugu INOUE   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Study on crack propagation of 42CrMo

Metalurgija, 2019
For the fatigue failure of 42CrMo, the tensile test was performed on the CT specimen at different load ratios using a fatigue tensile tester. Data on the fatigue crack growth rate of the material and the crack tip factor were obtained.
W. C. Pei, J. W. Dong, H. C. Ji, H. Y. Long, S. F. Yang   +4 more
doaj  

Crack Propagation in Axial-Flow Fan Blades Under Complex Loading Conditions: A FRANC3D and ABAQUS Co-Simulation Approach

Applied Sciences
Since fan blades are exposed to fatigue, and in some cases harsh loading conditions, they may exhibit fracture failures due to crack propagation, resulting in significant losses.
Mariem Ben Hassen, Slim Ben-Elechi, Hatem Mrad   +2 more
doaj   +1 more source